ArticlePloS one2017
Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Navigating the Forest of Lignin-Derived Monomers for Polymer Synthesis.Biomacromolecules · 2026Review
- Tetramethyl Bisphenol F: Organ- and System-Specific Toxicity, Current Status, and Perspectives.International journal of molecular sciences · 2025Review
- Effects of bisphenol A, bisphenol S, and tetramethyl bisphenol F on male fertility inToxicology and industrial health · 2025Article
- Mitigating Dietary Bisphenol Exposure Through the Gut Microbiota: The Role of Next-Generation Probiotics in Bacterial Detoxification.Nutrients · 2024Review
- A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals.Heliyon · 2024Article
- Binary Classification of the Endocrine Disrupting Chemicals by Artificial Neural Networks.ESCAPE. European Symposium on Computer Aided Process Engineering · 2023Article
- Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures.iScience · 2022Article
- Quality Control for Single Cell Imaging Analytics Using Endocrine Disruptor-Induced Changes in Estrogen Receptor Expression.Environmental health perspectives · 2022Article
- An insight into bisphenol A, food exposure and its adverse effects on health: A review.Frontiers in nutrition · 2022Review
- Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation.Molecules (Basel, Switzerland) · 2021Article
- BPA, BPAF and TMBPF Alter Adipogenesis and Fat Accumulation in Human Mesenchymal Stem Cells, with Implications for Obesity.International journal of molecular sciences · 2021Article
- Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development.Current research in toxicology · 2021Article
- Predicting the Estrogen Receptor Activity of Environmental Chemicals by Single-Cell Image Analysis and Data-driven Modeling.ESCAPE. European Symposium on Computer Aided Process Engineering · 2021Article
- Identification and Quantitation Studies of Migrants from BPA Alternative Food-Contact Metal Can Coatings.Polymers · 2020Article
- Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH.Journal of visualized experiments : JoVE · 2020Article
- Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms.PLoS computational biology · 2020Article
- A Mechanistic High-Content Analysis Assay Using a Chimeric Androgen Receptor That Rapidly Characterizes Androgenic Chemicals.SLAS discovery : advancing life sciences R & D · 2020Article
- Leveraging Image-Derived Phenotypic Measurements for Drug-Target Interaction Predictions.Cancer informatics · 2019Article
- Development of the Texas A&M Superfund Research Program Computational Platform for Data Integration, Visualization, and Analysis.ESCAPE. European Symposium on Computer Aided Process Engineering · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Animal studies have linked the estrogenic properties of bisphenol A (BPA) to adverse effects on the endocrine system. Because of concerns for similar effects in humans, there is a desire to replace BPA in consumer products, and a search for BPA replacements that lack endocrine-disrupting bioactivity is ongoing. We used multiple cell-based models, including an established multi-parametric, high throughput microscopy-based platform that incorporates engineered HeLa cell lines with visible ERα- or ERβ-regulated transcription loci, to discriminate the estrogen-like and androgen-like properties of previously uncharacterized substituted bisphenol derivatives and hydroquinone. As expected, BPA induced 70-80% of the estrogen-like activity via ERα and ERβ compared to E2 in the HeLa prolactin array cell line. 2,2' BPA, Bisguaiacol F, CHDM 4-hydroxybuyl acrylate, hydroquinone, and TM modified variants of BPF showed very limited estrogen-like or androgen-like activity (< 10% of that observed with the control compounds). Interestingly, TM-BFP and CHDM 4-hydroxybuyl acrylate, but not their derivatives, demonstrated evidence of anti-estrogenic and anti-androgenic activity. Our findings indicate that Bisguaiacol F, TM-BFP-ER and TM-BPF-DGE demonstrate low potential for affecting estrogenic or androgenic endocrine activity. This suggest that the tested compounds could be suitable commercially viable alternatives to BPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.