Evidence map›Paper›PMID 28703924›Full record

Observational studyNephrology (Carlton, Vic.)2018

Chronic kidney disease in Australian Human Immunodeficiency Virus-infected patients: Analysis of the Australian HIV Observational Database.

Jason Cheung, Rainer Puhr, Kathy Petoumenos, David A Cooper, Ian Woolley, Manoji Gunathilake, Nigel Raymond, Rick Varma, Catherine C O'Connor, David M Gracey

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Nephrology (Carlton, Vic.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Managing HIV infection in patients older than 50 years.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018
    Review
  10. Prevalence and risk factors of mild chronic renal failure in HIV-infected patients: influence of female gender and antiretroviral therapy.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Jason CheungRenal Unit, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia.
Rainer PuhrKirby Institute, UNSW Sydney, New South Wales, Australia.
Kathy PetoumenosKirby Institute, UNSW Sydney, New South Wales, Australia.
David A CooperKirby Institute, UNSW Sydney, New South Wales, Australia.
Ian WoolleyMonash Infectious Diseases, Monash University, Melbourne, Victoria, Australia.
Manoji GunathilakeKirby Institute, UNSW Sydney, New South Wales, Australia.
Nigel RaymondInfection Service, Capital & Coast DHB, Wellington, New Zealand.
Rick VarmaKirby Institute, UNSW Sydney, New South Wales, Australia.
Catherine C O'ConnorKirby Institute, UNSW Sydney, New South Wales, Australia.
David M GraceyRenal Unit, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia.
New South Wales Institute of Psychiatry · AURoyal Prince Alfred Hospital · AUCapital and Coast District Health Board · NZGovernment of Western Australia Department of Health · AUMonash University · AUSydney Sexual Health Centre · AU

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
Australian Government Department of HealthBoehringer IngelheimBristol-Myers SquibbEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentGilead SciencesMerck Sharp & DohmeNational Cancer InstituteNational Institute of Mental HealthNational Institute on Drug AbuseNIAID NIH HHS U01 AI069907The Foundation for AIDS ResearchUNSW AustraliaViiV Healthcare
6 · The paper itself

Abstract

aimThe aim of the present study was to examine data from the Australian HIV Observational Database (AHOD), and firstly, to describe the incidence of chronic kidney disease (CKD) and the rate of loss of renal function in HIV-infected individuals living in Australia, and then to examine the risk factors contributing to CKD in this population.

methodsAHOD patients over 18 years of age were eligible if they had at least two serum creatinine measurements from 1 April 2008 until 31 March 2016 and an initial estimated glomerular filtration rate (eGFR) greater than 60 mL/min per 1.73 m

resultsOf 1924 patients included in the analysis between April 2008 and March 2016, 81 (4.2%) developed CKD (confirmed eGFR of less than 60 mL/min per 1.73 m

conclusionThis is the first study to investigate the risk factors for development of CKD among Australian HIV-infected patients using cohort data. It highlights the need for awareness of renal risk factors, particularly among older patients or in those with pre-existing renal dysfunction. Further research is required to explore the discrepancy between patients who have acquired HIV through different means of exposure.

Indexed as

Glomerular Filtration RateAdultAIDS-Associated NephropathyAnti-HIV AgentsAustraliaBiomarkersCreatinineDatabases, FactualDisease ProgressionFemaleHIV InfectionsHumansIncidenceKidneyMaleMiddle AgedAnti-HIV AgentsBiomarkersCreatinineAIDS-associated nephropathychronicHIVHIV infectionskidney diseasesrenal insufficiency

Identifiers

PMID28703924
PMCPMC5799037
OpenAlexW2902750044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.