Evidence map›Paper›PMID 28703772›Full record

ArticleInternational journal of molecular sciences2017

Understanding the Inguinal Sinus in Sheep (Ovis aries)-Morphology, Secretion, and Expression of Progesterone, Estrogens, and Prolactin Receptors.

Graça Alexandre-Pires, Catarina Martins, António M Galvão, Margarida Miranda, Olga Silva, Dário Ligeiro, Telmo Nunes, Graça Ferreira-Dias

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Molecular Pathways of Estrogen Receptor Action.International journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Graça Alexandre-PiresCIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. Universidade Técnica, 1300-477 Lisboa, Portugal. gpires@fmv.ulisboa.pt.
Catarina MartinsCEDOC-Chronic Diseases Research Center, Immunology, NOVA Medical School, Universidade Nova de Lisboa, Rua Câmara Pestana n° 6, 6-A Edifício CEDOC II, 1150-082 Lisboa, Portugal. catarina.martins@fcm.unl.pt.
António M GalvãoCIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. Universidade Técnica, 1300-477 Lisboa, Portugal. agalvao@fmv.ulisboa.pt.
Margarida MirandaiMed.ULisboa, Pharmacological and Regulatory Sciences Group, Faculty of Pharmacy, Universidade de Lisboa, Av. Gama Pinto, 1649-003 Lisbon, Portugal. mimiranda@live.com.pt.
Olga SilvaiMed.ULisboa, Pharmacological and Regulatory Sciences Group, Faculty of Pharmacy, Universidade de Lisboa, Av. Gama Pinto, 1649-003 Lisbon, Portugal. odsilva@campus.ul.pt.
Dário LigeiroCentro de Sangue e Transplantação de Lisboa, IPST,IP Alameda das Linhas de Torres 117, 1749-005 Lisbon, Portugal. dario@ipst.min-saude.pt.
Telmo NunesMicroscopy Center, Faculty of Sciences, Campo Grande, 1749-016 Lisboa, Portugal. telmonunes@hotmail.com.
Graça Ferreira-DiasCIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. Universidade Técnica, 1300-477 Lisboa, Portugal. gmlfdias@fmv.ulisboa.pt.
University of Lisbon · PTUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-parturient behavior of mammalian females is essential for early parent-offspring contact. After delivery, lambs need to ingest colostrum for obtaining the related immunological protection, and early interactions between the mother and the lamb are crucial. Despite visual and auditory cues, olfactory cues are decisive in lamb orientation to the mammary gland. In sheep, the inguinal sinus is located bilaterally near the mammary gland as a skin pouch (IGS) that presents a gland that secretes a strong-smelling wax. Sheep IGS gland functions have many aspects under evaluation. The objective of the present study was to evaluate sheep IGS gland functional aspects and mRNA transcription and the protein expression of several hormone receptors, such as progesterone receptor (PGR), estrogen receptor 1 (ESR1), and 2 (ESR2) and prolactin receptor (PRLR) present. In addition, another aim was to achieve information about IGS ultrastructure and chemical compounds produced in this gland. All hormone receptors evaluated show expression in IGS during the estrous cycle (follicular/luteal phases), pregnancy, and the post-partum period. IGS secretion is rich in triterpenoids that totally differ from the surrounding skin. They might be essential substances for the development of an olfactory preference of newborns to their mothers.

Indexed as

AnimalsEstrogensFemaleFlow CytometryMammary Glands, AnimalPregnancyProgesteroneReceptors, ProlactinSheepEstrogensProgesteroneReceptors, Prolactinchemical compoundsESR1ESR2inguinal sinusmorphologyPGRPRLRtranscriptiontriterpenoids

Identifiers

PMID28703772
PMCPMC5536006
OpenAlexW2735432104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.