Evidence map›Paper›PMID 28703736›Full record

ArticleInternational journal of molecular sciences2017

Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury.

Zhi-Na Ma, Yan-Zi Li, Wei Li, Xiao-Tong Yan, Ge Yang, Jing Zhang, Li-Chun Zhao, Li-Min Yang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Nephroprotective Effect of BlackMolecules (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Nephroprotective Effects ofMolecules (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Article
  10. Review
  11. The nephroprotective effects ofBioengineered · 2021
    Article
  12. A neutral polysaccharide fromFood science & nutrition · 2021
    Article
  13. Article
  14. Cisplatin chemotherapy and renal function.Advances in cancer research · 2021
    Review
  15. Article
  16. Article
  17. Protective Effect of Low Molecular Weight Peptides fromAntioxidants (Basel, Switzerland) · 2020
    Article
  18. Article
  19. Supplementation of Saponins from Leaves ofAntioxidants (Basel, Switzerland) · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhi-Na MaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. mazhina9029@163.com.
Yan-Zi LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. liyanzi0401@126.com.
Wei LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. liwei7727@126.com.
Xiao-Tong YanCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. yanxiaotong0707@126.com.
Ge YangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. yangge1900@163.com.
Jing ZhangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. zhjing@163.com.
Li-Chun ZhaoCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530001, China. hyzlc@126.com.
Li-Min YangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. ylmh777@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although cisplatin is an anticancer drug that has activity against malignant tumor, it often causes nephrotoxicity. Previous reports have confirmed that the saponins from the leaves of

Indexed as

Acute Kidney InjuryAnimalsApoptosisCisplatinCytokinesGlutathioneInflammationKidneyMaleMalondialdehydeMice, Inbred ICRNeuroprotective AgentsOxidative StressPanaxPlant LeavesSaponinsCisplatinCytokinesGlutathioneMalondialdehydeNeuroprotective AgentsSaponinsSuperoxide Dismutaseanti-apoptosisanti-inflammationcisplatin-induced AKIginsenosidesthe leaves of Panax quinquefolium

Identifiers

PMID28703736
PMCPMC5535899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.