ArticleeLife2017
Dopamine neuron dependent behaviors mediated by glutamate cotransmission.
Abstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Aging-related vulnerability in dopamine-glutamate neurons weakens entorhinal dopamine signaling and underlies novelty discrimination deficits.Research square · 2026Article
- Multimodal characterization of transcriptionally defined ventral tegmental area dopamine neurons.bioRxiv : the preprint server for biology · 2026Article
- Evidence for age-related vulnerability in dopamine-glutamate projections to the lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Schizophrenia-associated changes in neuronal subpopulations in the human midbrain.Brain : a journal of neurology · 2025Article
- Dopamine-Glutamate and Dopamine-GABA Co-release.Advances in neurobiology · 2025Review
- Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress.Molecular psychiatry · 2024Article
- Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner.eLife · 2024Article
- Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release.Neuron · 2024Article
- The dopamine neuron synaptic map in the striatum.Cell reports · 2023Article
- Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia.Molecular psychiatry · 2022Review
- Subcellular and regional localization of mRNA translation in midbrain dopamine neurons.Cell reports · 2022Article
- The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders.Frontiers in physiology · 2022Review
- Metabolomics and Microbiomics: New Potential Strategies in Chronic Pain Syndrome.Journal of pain research · 2022Article
- Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression.Analytical and bioanalytical chemistry · 2021Article
- Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration.Aging cell · 2021Article
- Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior.Neurochemistry international · 2021Review
- Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse.The FEBS journal · 2021Review
- Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior.Frontiers in neural circuits · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Susana MingoteDepartment of Psychiatry, Columbia University, New York, United States.ORCID 0000-0002-0401-4317
Nao ChuhmaDepartment of Psychiatry, Columbia University, New York, United States.
Abigail KalmbachDepartment of Psychiatry, Columbia University, New York, United States.
Gretchen M ThomsenDepartment of Psychiatry, Columbia University, New York, United States.
Yvonne WangDepartment of Psychiatry, Columbia University, New York, United States.
Andra MihaliDepartment of Psychiatry, Columbia University, New York, United States.
Caroline SferrazzaDepartment of Psychiatry, Columbia University, New York, United States.ORCID 0000-0001-5861-111X
Ilana Zucker-ScharffDepartment of Psychiatry, Columbia University, New York, United States.
Anna-Claire SienaDepartment of Molecular Therapeutics, NYS Psychiatric Institute, New York, United States.
Martha G WelchDepartment of Psychiatry, Columbia University, New York, United States.
José Lizardi-OrtizDepartment of Neurology, Columbia University, New York, United States.
David SulzerDepartment of Psychiatry, Columbia University, New York, United States.ORCID 0000-0001-7632-0439
Holly MooreDepartment of Psychiatry, Columbia University, New York, United States.
Inna Gaisler-SalomonDepartment of Psychiatry, Columbia University, New York, United States.
Stephen RayportDepartment of Psychiatry, Columbia University, New York, United States.ORCID 0000-0001-9755-7486
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MThe Presynaptic Vesicle Cycle for the Slow Acting Neurotransmitter SecretionP01DA010154 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H, KREITZER, ANATOL · 1995 to 2016
$14.7MDopamine Dysfunction in SchizophreniaP50MH086404 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI ABI-DARGHAM, ANISSA · 2010 to 2014
$9.4MFunctional connectome analysis of amphetamine action at dopamine neuron synapsesR01DA038966 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RAYPORT, STEPHEN · 2015 to 2019
$2.9MTargeting cotransmission for circuit-specific pharmacotherapyR01MH117128 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RAYPORT, STEPHEN · 2018 to 2022
$2.9MTherapeutic potential of GLS1 inhibition for the pharmacotherapy of schizophreniaR01MH087758 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAYPORT, STEPHEN · 2010 to 2014
$1.8MTransgenic analysis of glutamate in sensitizationR01DA017978 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RAYPORT, STEPHEN · 2005 to 2009
$1.4MNCI NIH HHS P30 CA013696NIDA NIH HHS P01 DA010154NIDA NIH HHS R01 DA017978NIDA NIH HHS R01 DA038966NIMH NIH HHS P50 MH086404NIMH NIH HHS R01 MH087758NIMH NIH HHS R01 MH117128
Abstract
Dopamine neurons in the ventral tegmental area use glutamate as a cotransmitter. To elucidate the behavioral role of the cotransmission, we targeted the glutamate-recycling enzyme glutaminase (gene
Indexed as
Behavior, AnimalAction PotentialsAnimalsDopaminergic NeuronsGene Knockdown TechniquesGlutamic AcidGlutaminaseMiceVentral Tegmental AreaGLS1 protein, mouseGlutamic AcidGlutaminaseamphetamine sensitizationglutaminaselatent inhibitionmotivational saliencemouseneuroscienceresilience modelschizophrenia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.