Evidence map›Paper›PMID 28703694›Full record

ArticlePsychological science2017

When Is Higher Neuroticism Protective Against Death? Findings From UK Biobank.

Catharine R Gale, Iva Čukić, G David Batty, Andrew M McIntosh, Alexander Weiss, Ian J Deary

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Psychological science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Pooled it
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  6. Unraveling the brain-joint axis: genetic, transcriptomic, and cohort insights from neuroticism to osteoarthritis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  7. Neuroticism and sudden cardiac death: a prospective cohort study from UK biobank.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Catharine R Gale1 Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh.
Iva Čukić1 Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh.
G David Batty1 Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh.
Andrew M McIntosh1 Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh.
Alexander Weiss1 Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh.
Ian J Deary1 Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh.
University of Edinburgh · GBMRC Lifecourse Epidemiology Unit · GBUniversity College London · GB

Funding

Medical Research Council G0400491Medical Research Council MC_PC_12028Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council MR/K025023/1Medical Research Council MR/K026992/1Wellcome Trust
6 · The paper itself

Abstract

We examined the association between neuroticism and mortality in a sample of 321,456 people from UK Biobank and explored the influence of self-rated health on this relationship. After adjustment for age and sex, a 1- SD increment in neuroticism was associated with a 6% increase in all-cause mortality (hazard ratio = 1.06, 95% confidence interval = [1.03, 1.09]). After adjustment for other covariates, and, in particular, self-rated health, higher neuroticism was associated with an 8% reduction in all-cause mortality (hazard ratio = 0.92, 95% confidence interval = [0.89, 0.95]), as well as with reductions in mortality from cancer, cardiovascular disease, and respiratory disease, but not external causes. Further analyses revealed that higher neuroticism was associated with lower mortality only in those people with fair or poor self-rated health, and that higher scores on a facet of neuroticism related to worry and vulnerability were associated with lower mortality. Research into associations between personality facets and mortality may elucidate mechanisms underlying neuroticism's covert protection against death.

Indexed as

Cause of DeathDiagnostic Self EvaluationHealth StatusNeuroticismAdultAgedBiological Specimen BanksFemaleHumansMaleMiddle AgedPregnancyUnited Kingdomcohort studymortalityneuroticismself-rated health

Identifiers

PMID28703694
PMCPMC5595241
OpenAlexW2734910564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.