ReviewAngewandte Chemie (International ed. in English)2017
Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH.
Review in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 478 citations in OpenAlex.
- Activatable NIR Schaap's 1,2-Dioxetane-Based Chemiluminescent Probes for Bioimaging Applications.Chemical & biomedical imaging · 2026Review
- A Grignard-mediated route to access 4-substituted-3-RSC advances · 2026Article
- A fluorescent probe for concurrent detection of cysteine, homocysteine, and superoxide anion.Science advances · 2025Article
- A review of metal ion complexation/decomplexation reaction-based fluorescent sensors for detecting biological thiols.RSC advances · 2025Review
- Naphthalimide-Based Type-I Nano-Photosensitizers for Enhanced Antitumor Photodynamic Therapy: HAngewandte Chemie (International ed. in English) · 2025Article
- A mercury complex-based fluorescent sensor for biological thiols.RSC advances · 2025Article
- Activatable Photosensitizers: From Fundamental Principles to Advanced Designs.Angewandte Chemie (International ed. in English) · 2025Review
- Precision Imaging of Biothiols in Live Cells and Treatment Evaluation during the Development of Liver Injury via a Near-Infrared Fluorescent Probe.Chemical & biomedical imaging · 2025Article
- Smart Probes for Ultrasensitive and Highly Selective Sensing of Homocysteine over Cysteine Based on Multi-Cooperative Effects by Using Gold Nanoparticles.Molecules (Basel, Switzerland) · 2025Article
- A lysosome-targeted fluorescent probe with large Stokes shift for visualizing biothiolsiScience · 2024Article
- Sensing Mechanism of Cysteine Specific Fluorescence Probes and Their Application of Cysteine Recognition.Chemical & biomedical imaging · 2024Review
- Cysteine and homocysteine can be exploited by GPX4 in ferroptosis inhibition independent of GSH synthesis.Redox biology · 2024Article
- Phosphorescent iridium (III) complex with covalent organic frameworks as scaffolds for highly selective and sensitive detection of homocysteine.Frontiers in chemistry · 2024Article
- Applications of Pyrrole and Pyridine-based Heterocycles in Cancer Diagnosis and Treatment.Current pharmaceutical design · 2024Review
- Atomic electronegativity-dependent intramolecular hydrogen bond and fluorescence characteristics of novel scaffold-based fluorophore: a TD-DFT study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- A Reversible Dual-Channel Near-Infrared Flavonoid Probe forChemical & biomedical imaging · 2023Article
- Functional Nucleic Acid Probes Based on Two-Photon for Biosensing.Biosensors · 2023Review
- Reactive Oxygen Species: A Crosslink between Plant and Human Eukaryotic Cell Systems.International journal of molecular sciences · 2023Review
- Sensitive and discriminative detection of cysteine by a Nile red-based NIR fluorescence probe.Analytical and bioanalytical chemistry · 2023Article
- Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play crucial roles in maintaining redox homeostasis in biological systems. This Minireview summarizes the most significant current challenges in the field of thiol-reactive probes for biomedical research and diagnostics, emphasizing the needs and opportunities that have been under-investigated by chemists in the selective probe and sensor field. Progress on multiple binding site probes to distinguish Cys, Hcy, and GSH is highlighted as a creative new direction in the field that can enable simultaneous, accurate ratiometric monitoring. New probe design strategies and researcher priorities can better help address current challenges, including the monitoring of disease states such as autism and chronic diseases involving oxidative stress that are characterized by divergent levels of GSH, Cys, and Hcy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.