Evidence map›Paper›PMID 28703425›Full record

ArticleJournal of diabetes2018

Optimism, pessimism, cynical hostility, and biomarkers of metabolic function in the Women's Health Initiative.

Hilary A Tindle, Meredith S Duncan, Simin Liu, Lewis H Kuller, Nancy Fugate Woods, Steve R Rapp, Candyce H Kroenke, Mace Coday, Eric B Loucks, Michael J Lamonte and 5 more

Abstract read
In one paragraph

Article in Journal of diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
  5. Yin and Yang of Psychological Health in the Cancer Experience: Does Positive Psychology Have a Role?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hilary A TindleVanderbilt University Medical Center, Nashville, Tennessee, USA.
Meredith S DuncanVanderbilt University Medical Center, Nashville, Tennessee, USA.
Simin LiuBrown University, Providence, Rhode Island, USA.
Lewis H KullerUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nancy Fugate WoodsUniversity of Washington, School of Nursing, Seattle,Washington, USA.
Steve R RappWake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, North Carolina, USA.
Candyce H KroenkeKaiser Permanente Northern California, Oakland, California, USA.
Mace CodayUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA.
Eric B LoucksBrown University, Providence, Rhode Island, USA.
Michael J LamonteUniversity at Buffalo, Buffalo, New York, USA.
Ana M ProgovacHarvard Medical School, Boston, Massachusetts, USA.
Elena Salmoirago-BlotcherBrown University, Providence, Rhode Island, USA.ORCID http://orcid.org/0000-0003-4636-8698
Brian T WalittNational Institutes of Health, Bethesda, Maryland, USA.
Nai-Chieh Y YuoUniversity of California, Los Angeles, California, USA.
Matthew S FreibergVanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

Health Policy Training Program: Promoting Outcomes, Quality, Equity and Diffusion of AdvancesT32MH019733 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Benjamin Le Cook, Haiden A Huskamp · 1993 to 2026
$7.0M
Vanderbilt Center for Diabetes Translation ResearchP30DK092986 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELASY, TOM A · 2011 to 2020
$6.7M
NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS P30 DK092986NIMH NIH HHS T32 MH019733WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundPsychological attitudes reflecting expectations about the future (optimism, pessimism) and people (cynical hostility) independently predict incident cardiovascular disease and possibly diabetes, but underlying biologic pathways are incompletely understood. Herein we examined the cross-sectional relationship between optimism, pessimism, and cynicism and biomarkers of metabolic function in the Women's Health Initiative.

methodsAmong 3443 postmenopausal women, biomarkers of metabolic function (fasting insulin [FINS] and glucose) were measured at baseline and used to calculate insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]) and pancreatic β-cell activity (homeostasis model assessment of β-cell function [HOMA-B]). Psychological attitudes were assessed by the Life Orientation Test, Revised (full scale, and optimism and pessimism subscales) and the Cook-Medley cynicism subscale. Multivariable linear regression modeled the association of psychological attitudes with biomarker levels, adjusting for sociodemographics, health conditions, and health behaviors. Because obesity promotes insulin resistance and obese individuals tend to report higher levels of pessimism and cynical hostility, an interaction with body mass index (BMI) was explored.

resultsIn fully adjusted models, only pessimism remained independently associated with higher FINS and insulin resistance (HOMA-IR). Scoring 1 point higher on the pessimism subscale was associated with a 1.2% higher FINS, whereas scoring 1 SD higher was associated with a 2.7% higher FINS (P = 0.03); results were similar for HOMA-IR. An interaction term with BMI was not significant.

conclusionsIn multivariable models, higher dispositional pessimism was associated with worse metabolic function; these findings were not modified by obesity status. Results extend prior work by linking pessimism to an objective biomarker of insulin resistance in elderly women.

Indexed as

Health BehaviorHostilityWomen's HealthAgedBiomarkersCross-Sectional StudiesFemaleFollow-Up StudiesHumansInsulin ResistanceMetabolic DiseasesMiddle AgedOptimismPessimismPrognosisRisk FactorsBiomarkerscynical hostilitydiabetesinsulin resistanceoptimismpessimism乐观情绪悲观情绪愤世嫉俗型敌意糖尿病胰岛素抵抗

Identifiers

PMID28703425
PMCPMC8835287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.