Evidence map›Paper›PMID 28703219›Full record

ArticleNature communications2017

Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer.

Ho-Young Son, Yul Hwangbo, Seong-Keun Yoo, Sun-Wha Im, San Duk Yang, Soo-Jung Kwak, Min Seon Park, Soo Heon Kwak, Sun Wook Cho, Jun Sun Ryu and 12 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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  18. Genetic susceptibility to hereditary non-medullary thyroid cancer.Hereditary cancer in clinical practice · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Ho-Young SonDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Yul HwangboDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Seong-Keun YooDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Republic of Korea.
Sun-Wha ImDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
San Duk YangDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Republic of Korea.
Soo-Jung KwakDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Republic of Korea.
Min Seon ParkDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Soo Heon KwakDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Sun Wook ChoDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Jun Sun RyuCenter for Thyroid Cancer, National Cancer Center, Goyang 10408, Republic of Korea.
Jeongseon KimMolecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Yuh-Seog JungCenter for Thyroid Cancer, National Cancer Center, Goyang 10408, Republic of Korea.
Tae Hyun KimCenter for Thyroid Cancer, National Cancer Center, Goyang 10408, Republic of Korea.
Su-Jin KimDepartment of Surgery, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Kyu Eun LeeDepartment of Surgery, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Do Joon ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Nam Han ChoDepartment of Preventive Medicine Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Joohon SungDepartment of Epidemiology and Institute of Environment and Health, School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Jeong-Sun SeoDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Eun Kyung LeeCenter for Thyroid Cancer, National Cancer Center, Goyang 10408, Republic of Korea.
Young Joo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Jong-Il KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.ORCID 0000-0002-7240-3744
Seoul National University · KRNational Cancer Center · KRAjou University · KRNorthwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid cancer is the most common cancer in Korea. Several susceptibility loci of differentiated thyroid cancer (DTC) were identified by previous genome-wide association studies (GWASs) in Europeans only. Here we conducted a GWAS and a replication study in Koreans using a total of 1,085 DTC cases and 8,884 controls, and validated these results using expression quantitative trait loci (eQTL) analysis and clinical phenotypes. The most robust associations were observed in the NRG1 gene (rs6996585, P=1.08 × 10

Indexed as

Genetic Predisposition to DiseaseQuantitative Trait LociAdultFemaleForkhead Transcription FactorsGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedNeoplasm ProteinsPolymorphism, Single NucleotideProto-Oncogene Proteins c-vavThyroid NeoplasmsThyroid Nuclear Factor 1Forkhead Transcription FactorsFOXE1 protein, humanNeoplasm ProteinsNKX2-1 protein, humanPCNX2 protein, humanProto-Oncogene Proteins c-vavThyroid Nuclear Factor 1VAV3 protein, human

Identifiers

PMID28703219
PMCPMC5511346
OpenAlexW2734395071

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.