ArticleNature communications2017
Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex.The European journal of neuroscience · 2025Article
- Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice.Nature communications · 2023Article
- Targeted approaches to delineate neuronal morphology during early development.Frontiers in cellular neuroscience · 2023Review
- Article
- Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing.Cell research · 2022Article
- Origin, Development, and Synaptogenesis of Cortical Interneurons.Frontiers in neuroscience · 2022Review
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- The Emergence of Network Activity Patterns in the Somatosensory Cortex - An Early Window to Autism Spectrum Disorders.Neuroscience · 2021Review
- The role of cell lineage in the development of neuronal circuitry and function.Developmental biology · 2021Review
- Neurophysiology of the Developing Cerebral Cortex: What We Have Learned and What We Need to Know.Frontiers in cellular neuroscience · 2021Review
- Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits.Frontiers in neural circuits · 2021Review
- GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex.Neuron · 2020Article
- Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis.Nature communications · 2019Article
- Neuronal specification in space and time.Science (New York, N.Y.) · 2018Review
- Neural lineage tracing in the mammalian brain.Current opinion in neurobiology · 2018Review
- Article
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Authors and funding
6 authors.
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Abstract
GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other. This lineage-related electrical coupling forms predominantly between the same interneuron subtype over an extended postnatal period and across a range of distances, and promotes action potential generation and synchronous firing. Interestingly, this selective electrical coupling relates to a coordinated inhibitory chemical synapse formation between sparsely labelled interneurons in clusters and the same nearby excitatory neurons. These results suggest a link between the lineage relationship of neocortical interneurons and their precise functional organization.
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