Evidence map›Paper›PMID 28703124›Full record

Trial reportJournal of human hypertension2017

Comparison between the effects of hydrochlorothiazide and indapamide on the kidney in hypertensive patients inadequately controlled with losartan.

S Wang, J Li, X Zhou, K Liu, X Zhang, Q Meng, R Shi, D Shi, X Chen

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of human hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

S WangDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
J LiDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
X ZhouDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
K LiuDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
X ZhangDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
Q MengDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
R ShiDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
D ShiDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
X ChenDepartment of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
West China Hospital of Sichuan University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study is to compare the effects of hydrochlorothiazide and indapamide on the kidney in patients with hypertension inadequately controlled with losartan. A total of 140 patients who met the criteria and inadequately controlled with losartan 50 mg per day for 2 weeks were randomized in two groups and administered either hydrochlorothiazide 12.5 mg per day (n=70) or indapamide (sustained release) 1.5 mg per day (n=70) in combination with losartan 50 mg per day. Office blood pressure (BP) were collected at baseline and upon each follow-up visit. Creatinine, urine albumin-creatinine ratio (ACR), urine neutrophil gelatinase-associated lipocalin (NGAL) and renal resistive index (RRI) were also collected at baseline and at the 24-week follow-up. None of the baseline characteristics was statistically significantly different between the two groups. After excluding those patients with office BP uncontrolled, 46 patients in the hydrochlorothiazide group (45.7% males, 58.8±10.8 years) and 44 patients in the indapamide group (38.4% males, 61.5±10.9 years) were analysed. There were insignificant changes in creatinine and significant decreases in ACR, NGAL and RRI compared to baseline levels in the two groups. The decrease in ACR (3.8 (0, 28.7) vs 4.2 (0.4, 64.8) mg g

Indexed as

AgedAntihypertensive AgentsBlood PressureCreatinineFemaleHumansHydrochlorothiazideHypertensionIndapamideKidneyLipocalin-2LosartanMaleMiddle AgedProspective StudiesTreatment FailureAntihypertensive AgentsCreatinineHydrochlorothiazideIndapamideLCN2 protein, humanLipocalin-2Losartan

Identifiers

PMID28703124
OpenAlexW2734563409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.