Trial reportMolecular imaging and biology2018
Oxygenation Status in Chronic Leg Ulcer After Topical Hemoglobin Application May Act as a Surrogate Marker to Find the Best Treatment Strategy and to Avoid Ineffective Conservative Long-term Therapy.
Trial report in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of the efficacy of topical haemoglobin therapy for wound healing.International wound journal · 2020Pooled it
- A primer on current status and future opportunities of clinical optoacoustic imaging.Npj imaging · 2025Review
- Evaluations of a Cutaneous Wound Healing Model Using Oxygen Enhanced - Dynamic Contrast Enhanced Photoacoustic Imaging (OE-DCE PAI).Molecular imaging and biology · 2024Article
- Dynamic characterization of vascular response and treatment in oral traumatic ulcer in mice via photoacoustic imaging.Quantitative imaging in medicine and surgery · 2024Article
- Mini review of photoacoustic clinical imaging: a noninvasive tool for disease diagnosis and treatment evaluation.Journal of biomedical optics · 2024Review
- Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia.Cells · 2023Article
- Venous, Arterial, and Neuropathic Leg Ulcers With Emphasis on the Geriatric Population.Cureus · 2023Review
- [Research advances on the role of hemoglobin spray in chronic wounds].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Photoacoustic imaging for the monitoring of local changes in oxygen saturation following an adrenaline injection in human forearm skin.Biomedical optics express · 2021Article
- A review of clinical photoacoustic imaging: Current and future trends.Photoacoustics · 2019Review
- Photoacoustic Oxygenation Quantification in Patients with Raynaud's: First-in-Human Results.Ultrasound in medicine & biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChronic leg ulcers can be a challenge to treat and long-term therapy a significant cost factor in western public health budgets. Objective wound assessment assays enabling selection of appropriate wound therapy regimes would be desirable. Oxygenation status in ulcer tissue has obtained increased attention as a relevant factor in wound healing. To increase oxygenation in wounds, a topical hemoglobin spray was developed. Although favorable results have been noted, the link between clinical efficacy and the mode of action has not been demonstrated. The aims were to determine if changes in tissue oxygenation can be measured after topical application of hemoglobin on chronic wounds and to evaluate the findings in terms of therapy strategies. PROCEDURES: Photoacoustic imaging was used to measure the local oxygen saturation (StO
resultsMeasuring 49 patients, an increase in StO
conclusionOur findings suggest that the likelihood of wound healing under conservative therapy can be predicted by measuring changes in StO
trial registrationGerman Clinical Trials Register: DRKS00005993.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.