Evidence map›Paper›PMID 28702887›Full record

ArticleEndocrine2018

Ambulatory blood pressure monitoring-derived short-term blood pressure variability in primary hyperparathyroidism.

A Concistrè, A Grillo, G La Torre, R Carretta, B Fabris, L Petramala, C Marinelli, A Rebellato, F Fallo, C Letizia

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In one paragraph

Article in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Blood Pressure Variability (BPV): What Clinicians Need to Know a 2025 Expert Consensus Report Endorsed by the Egyptian Society of Cardiology.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

A ConcistrèDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy.
A GrilloDepartment of Medicine and Surgery, University of Milano Bicocca, Milan, Italy.
G La TorreDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy.
R CarrettaDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
B FabrisDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
L PetramalaDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy.
C MarinelliDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy.
A RebellatoDepartment of Medicine-DIMED, University of Padova, Padova, Italy.
F FalloDepartment of Medicine-DIMED, University of Padova, Padova, Italy.
C LetiziaDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy. claudio.letizia@uniroma1.it.ORCID 0000-0003-4397-0624
Sapienza University of Rome · ITUniversity of Padua · ITUniversity of Trieste · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrimary hyperparathyroidism is associated with a cluster of cardiovascular manifestations, including hypertension, leading to increased cardiovascular risk. PURPOSE: The aim of our study was to investigate the ambulatory blood pressure monitoring-derived short-term blood pressure variability in patients with primary hyperparathyroidism, in comparison with patients with essential hypertension and normotensive controls.

methodsTwenty-five patients with primary hyperparathyroidism (7 normotensive,18 hypertensive) underwent ambulatory blood pressure monitoring at diagnosis, and fifteen out of them were re-evaluated after parathyroidectomy. Short-term-blood pressure variability was derived from ambulatory blood pressure monitoring and calculated as the following: 1) Standard Deviation of 24-h, day-time and night-time-BP; 2) the average of day-time and night-time-Standard Deviation, weighted for the duration of the day and night periods (24-h "weighted" Standard Deviation of BP); 3) average real variability, i.e., the average of the absolute differences between all consecutive BP measurements.

resultsBaseline data of normotensive and essential hypertension patients were matched for age, sex, BMI and 24-h ambulatory blood pressure monitoring values with normotensive and hypertensive-primary hyperparathyroidism patients, respectively. Normotensive-primary hyperparathyroidism patients showed a 24-h weighted Standard Deviation (P < 0.01) and average real variability (P < 0.05) of systolic blood pressure higher than that of 12 normotensive controls. 24-h average real variability of systolic BP, as well as serum calcium and parathyroid hormone levels, were reduced in operated patients (P < 0.001). A positive correlation of serum calcium and parathyroid hormone with 24-h-average real variability of systolic BP was observed in the entire primary hyperparathyroidism patients group (P = 0.04, P  = 0.02; respectively).

conclusionSystolic blood pressure variability is increased in normotensive patients with primary hyperparathyroidism and is reduced by parathyroidectomy, and may potentially represent an additional cardiovascular risk factor in this disease.

Indexed as

AdultAgedBlood PressureBlood Pressure Monitoring, AmbulatoryCross-Sectional StudiesFemaleHumansHyperparathyroidism, PrimaryMaleMiddle AgedParathyroidectomyABPMHypertensionPrimary hyperparathyroidismShort-term blood pressure variability

Identifiers

PMID28702887
OpenAlexW2735760373

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.