Evidence map›Paper›PMID 28702868›Full record

SynthesisWorld journal of pediatrics : WJP2017

Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies.

Qian-Yun Cai, Zhong-Jie Zhou, Rong Luo, Jing Gan, Shi-Ping Li, De-Zhi Mu, Chao-Min Wan

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of pediatrics : WJP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04292938 (Ketogenic Diet in McArdle Disease), which is not on this map. Cited by 68 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 5 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04292938 nacompletednot on this mapstarted 2019, after this paper: background citation

Ketogenic Diet in McArdle Disease: a Multicentric Single Blind Controlled Trial

TypeinterventionalSponsorIRCCS Eugenio MedeaRan2019 to 2021Enrolled16ConditionsGlycogen Storage DiseaseArmsLow carbohydrate ketogenic diet
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qian-Yun CaiDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Zhong-Jie ZhouDepartment of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
Rong LuoDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Jing GanKey Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China.
Shi-Ping LiKey Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China.
De-Zhi MuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Chao-Min WanDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. wcm0220@sina.com.
Sichuan University · CNWest China Second University Hospital of Sichuan University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo review the available evidence from prospective studies on the safety and tolerability of the ketogenic diet (KD) for the treatment of refractory childhood epilepsy.

methodsA comprehensive bibliographic search was performed with the aim of retrieving prospective studies that monitored adverse effects (AEs) in children after receiving the classic or medium-chain triglyceride KD therapy for refractory epilepsy.

resultsA total of 45 studies were retrieved, including 7 randomized controlled trials. More than 40 categories of AEs were reported. The most common AEs included gastrointestinal disturbances (40.6%), hyperlipidemia (12.8%), hyperuricemia (4.4%), lethargy (4.1%), infectious diseases (3.8%) and hypoproteinemia (3.8%). Severe AEs, such as respiratory failure and pancreatitis, occurred in no more than 0.5% of children. Specifically, patients receiving KD therapy should be monitored for osteopenia, urological stones, right ventricular diastolic dysfunction, and growth disturbance. The total retention rates of the diet for 1 year and 2 years were 45.7% and 29.2%, respectively. Nearly half of the patients discontinued the diet because of lack of efficacy. AEs were not the main reason for the KD discontinuation. None of the 24 deaths reported after initiation of the diet was attributed to the KD.

conclusionsKD is a relatively safe dietary therapy. However, because the KD can cause various AEs, it should be implemented under careful medical supervision. Continuous follow-up is needed to address the long-term impact of the diet on the overall health of children.

Indexed as

AdolescentChildChild, PreschoolChinaDiet, KetogenicDrug Resistant EpilepsyFemaleHumansInfantMalePatient SafetyPrognosisProspective StudiesRisk AssessmentSeverity of Illness IndexTreatment Outcomeadverse effectsketogenic dietprospective studiesrefractory childhood epilepsytolerability

Identifiers

PMID28702868
OpenAlexW2735850363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.