ArticleAnnals of surgical oncology2017
Oncologic Outcomes After Treatment for MRI Occult Breast Cancer (pT0N+).
Article in Annals of surgical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Best treatment options for occult breast cancer: A meta-analysis.Frontiers in oncology · 2023Pooled it
- Is Mastectomy Necessary in Patients with Occult Breast Cancer and Advanced (N2/N3) Nodal Disease?Annals of surgical oncology · 2026Observational
- ASO Author Reflections: Rethinking Local Therapy for Occult Breast Cancer with Advanced Nodal Disease.Annals of surgical oncology · 2026Article
- Occult Breast Carcinoma: Pathologic Features of an Uncommon Clinical Presentation in a Large Cohort.The American journal of surgical pathology · 2026Article
- Shifting from axillary dissection to targeted axillary surgery after neoadjuvant treatment: the evolving management of occult breast cancer in a monoinstitutional series of 114 patients.Breast cancer research and treatment · 2025Article
- Occult breast cancer in an older woman: A case report.Experimental and therapeutic medicine · 2025Article
- Trends in management and related outcomes for occult primary breast cancer.Breast cancer research and treatment · 2025Article
- Clinicopathologic features and genomic profiling of female axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary.Journal of cancer research and clinical oncology · 2024Article
- Analysis of Prognoses according to Breast MRI Results in Patients with Axillary Lymph Node Metastases from an Unknown Primary Origin.Yonsei medical journal · 2023Article
- Survival analysis and nomogram for early-stage occult breast cancer with positive lymph nodes based on the SEER database.Annals of translational medicine · 2022Article
- Axillary lymph node dissection plus radiotherapy may be an optimal strategy for patients with occult breast cancer.Journal of the National Cancer Center · 2022Article
- Clinicopathological characteristics and treatment outcomes of occult breast cancer: a population-based study.BMC surgery · 2022Article
- Prediction for Distant Metastasis of Breast Cancer Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging Images under Deep Learning.Computational intelligence and neuroscience · 2022Article
- Prognosis of patients with axillary lymph node metastases from occult breast cancer: analysis of multicenter data.Radiation oncology journal · 2021Article
- Axillary Nodal Metastases from Carcinoma of Unknown Primary (CUPAx): Role of Contrast-Enhanced Spectral Mammography (CESM) in Detecting Occult Breast Cancer.Journal of personalized medicine · 2021Article
- Occult breast cancer: Where are we at?Breast (Edinburgh, Scotland) · 2020Review
- Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI.Breast (Edinburgh, Scotland) · 2020Article
- The effect of local therapy on breast cancer-specific mortality of women with occult breast cancer and advanced nodal disease (N2/N3): a population analysis.Breast cancer research and treatment · 2019Article
- Occult Breast Carcinoma Presenting with Extensive Bone Involvement in the Absence of an Identifiable Primary Breast Lesion: A Case Report.Journal of investigative medicine high impact case reportsReview
- Ipsilateral Breast Tumor Detected 20 Years after Occult Breast Cancer: A Diagnostic Challenge in Distinguishing New Primary Cancer from Late Recurrence.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundStudies assessing outcomes in occult breast cancer have often included women treated before the routine use of magnetic resonance imaging (MRI). This study examined outcomes for patients presenting with axillary adenopathy and no primary breast tumor detectable by MRI or other imaging methods.
methodsAll patients with axillary nodal metastases consistent with breast carcinoma and no breast primary tumor detectable by physical exam, mammography, or MRI treated between 1 January 1996 and 30 June 2011 were identified from an institutional database. Data were collected on local, regional, and distant recurrences.
resultsFor the study, 38 patients were identified. Modified radical mastectomy (MRM) was performed for 13 of the patients, whereas 25 of the patients underwent axillary dissection (ALND) and whole-breast radiotherapy (WBRT). Most of the women had pathologic N1 disease [median number of positive nodes, 2 (MRM cohort) and 3 (ALND + WBRT cohort); p = 0.38]. All the patients received chemotherapy, and 30 (79%) of the 38 patients received an anthracycline and taxane. Regional nodal radiation was used for 60% of those with ALND + WBRT and for all 46% of the MRM patients who received chest wall radiotherapy. During a median follow-up period of 7 years, there were no nodal recurrences. Two patients treated with ALND + WBRT had in-breast recurrences, whereas none in the MRM group experienced a local recurrence. The proportion that experienced distant disease was similar between the MRM cohort (1 of 13) and the ALND + WBRT cohort (2 of 25).
conclusionBreast cancer presenting as axillary adenopathy with no detectable primary tumor is rare. Breast conservation with WBRT is a viable option for patients with a diagnosis of occult breast cancer and a negative preoperative MRI.
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