Evidence map›Paper›PMID 28702721›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2017

Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.

P A Slominsky, M I Shadrina, T A Kolomin, A V Stavrovskaya, E V Filatova, L A Andreeva, S N Illarioshkin, N F Myasoedov

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

P A SlominskyInstitute of Molecular Genetics RAS, Moscow, Russia.
M I ShadrinaInstitute of Molecular Genetics RAS, Moscow, Russia.
T A KolominInstitute of Molecular Genetics RAS, Moscow, Russia.
A V StavrovskayaScientific Centre of Neurology, Moscow, Russia.
E V FilatovaInstitute of Molecular Genetics RAS, Moscow, Russia. filatovaev@img.ras.ru.
L A AndreevaInstitute of Molecular Genetics RAS, Moscow, Russia.
S N IllarioshkinScientific Centre of Neurology, Moscow, Russia.
N F MyasoedovInstitute of Molecular Genetics RAS, Moscow, Russia.
Institute of Molecular Genetics · RUResearch Center of Neurology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common severe neurodegenerative disorder that is characterized by progressive degeneration of dopaminergic neurons (DA neurons) in the substantia nigra pars compacta (SNpc) region of the brain. In the present study, we investigated the effects of the synthetic regulatory peptides Semax (analog of an ACTH 4-10 fragment (ACTH4-10)) and Selank (analog of immunomodulatory taftsin) on behavior of rats with 6-hydroxidopamine (6-OHDA) induced PD-like parkinsonism. It was showed that both peptides did not affect motor activity of rats in elevated cross shaped maze and passive defensive behavior of the animals. At the same time, Selank decreased level of anxiety of rats with toxic damage of DA neurons in elevated cross shaped maze. Previously such effects of Selank were revealed in healthy rodents (rats and mice) with different models of psycho-emotional stress. Therefore, toxic damage of substantia nigra does not affect the response of the rat organism on this peptide.

Indexed as

Adrenocorticotropic HormoneAnimalsAnxietyDisease Models, AnimalDopaminergic NeuronsMaleOligopeptidesOxidopamineParkinson DiseaseParkinsonian DisordersPars CompactaPeptide FragmentsRatsACTH (4-7), Pro-Gly-Pro-Adrenocorticotropic HormoneOligopeptidesOxidopaminePeptide FragmentsTP 7

Identifiers

PMID28702721
OpenAlexW2736117548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.