Evidence map›Paper›PMID 28702514›Full record

ArticleNeuro : open journal2015

Emerging Role of the Cerebrospinal Fluid - Neuronal Interface in Neuropathology.

Vanessa Ochoa, Annalee J Loeffler, Christie D Fowler

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro : open journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vanessa OchoaDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Annalee J LoefflerDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Christie D FowlerDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
University of California, Irvine · US

Funding

Circulating miRNAs and Epigenetic Regulation in Nicotine AddictionDP1DA039658 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FOWLER, CHRISTIE D · 2015 to 2019
$2.3M
The Habenulo-Interpeduncular Pathway and NicotineR00DA032543 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FOWLER, CHRISTIE D · 2014 to 2016
$741k
The Habenulo-Interpeduncular Pathway and NicotineK99DA032543 · NIDA · SCRIPPS FLORIDA · PI FOWLER, CHRISTIE D · 2012 to 2013
$297k
The alpha5 Nicotinic Acetylcholine Receptor Subunit in Nicotine DependenceF32DA026693 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI FOWLER, CHRISTIE D · 2009 to 2011
$168k
NIDA NIH HHS DP1 DA039658NIDA NIH HHS F32 DA026693NIDA NIH HHS K99 DA032543NIDA NIH HHS R00 DA032543
6 · The paper itself

Abstract

The choroid plexus and cerebrospinal fluid have recently begun to emerge as essential regulators of neural function. Factors produced by the choroid plexus are released into the ventricular environment and thus provide a rich source of extracellular signaling molecules throughout the central nervous system. Identified factors in the cerebrospinal fluid include growth factors, hormones, proteins, peptides, lipids, glucose, microRNAs (miRNAs), messenger RNA (mRNA), and enzymes. In addition to mediating neural function, these factors have the potential to serve as biomarkers of disease states. In this review, we highlight recent advances demonstrating the importance of extracellular signaling mechanisms in mediating neural function and provide recent evidence for their role in neuropathology.

Indexed as

Cerebrospinal fluidChoroid plexusExtracellular communicationMicrovesiclesNeuropathology

Identifiers

PMID28702514
PMCPMC5502773
OpenAlexW2606601350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.