Evidence map›Paper›PMID 28702493›Full record

ArticleData in brief2017

Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide.

Li Wang, Aili Wang, William W Supplee, Kayla Koffler, Ying Cheng, Zenaide M N Quezado, Richard J Levy

Abstract read
In one paragraph

Article in Data in brief, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li WangThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Division of Pain Medicine, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United States.
Aili WangDepartment of Anesthesiology, Columbia University Medical Center, United States.
William W SuppleeRutgers New Jersey Medical School, United States.
Kayla KofflerDepartment of Anesthesiology, Columbia University Medical Center, United States.
Ying ChengCenter for Genetic Medicine Research, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United States.
Zenaide M N QuezadoThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Division of Pain Medicine, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United States.
Richard J LevyDepartment of Anesthesiology, Columbia University Medical Center, United States.

Funding

Carbon monoxide exposure and anesthesia-induced neurotoxicityR01GM103842 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEVY, RICHARD J · 2013 to 2017
$1.5M
Neurobiology of pain and behavior changes associated with rare diseases and developmental disabilitiesZIACL090052 · CLC · CLINICAL CENTER · PI QUEZADO, ZENAIDE · 2017 to 2025
$0k
NIGMS NIH HHS R01 GM103842
6 · The paper itself

Abstract

The data presented here detail the changes in size, cellular content, and neuronal density of the developing brain over time with respect to sex in C57Bl/6 mice following neonatal exposure to isoflurane, carbon monoxide, or their combination. Specifically, brain weight- and brain volume-to-body weight ratios are presented, representative immunoblots of whole brain cell-specific protein content are depicted, and quantification of the number of neurons in the primary somatosensory cortex and CA3 region of the hippocampus are shown. Three discrete postnatal time points are represented: P7 (prior to exposure), P14 (one-week post exposure), and P42-56 (5-7 weeks post exposure). Major findings from the data presented here are reported in the manuscript "Carbon Monoxide Incompletely Prevents Isoflurane-induced Defects in Murine Neurodevelopment" (Wang et al., in press) [1].

Identifiers

PMID28702493
PMCPMC5491399

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.