ArticleOpen forum infectious diseases2017
Malaria and Chikungunya Detected Using Molecular Diagnostics Among Febrile Kenyan Children.
Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Epidemiology of human and animal leptospirosis in Kenya: A systematic review and meta-analysis of disease occurrence, serogroup diversity and risk factors.PLoS neglected tropical diseases · 2024Pooled it
- A systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.PLoS neglected tropical diseases · 2022Pooled it
- Chikungunya fever in Africa: a systematic review.Pathogens and global health · 2020Pooled it
- Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review.BMC public health · 2018Pooled it
- Serendipitous detection of invasive malaria vector Anopheles stephensi in Kisumu, Kenya in June 2022.Scientific reports · 2026Article
- Sociodemographic and ecological factors associated with malaria and malaria recurrence risk in children in Msambweni, Kwale County, Kenya.Malaria journal · 2025Article
- Modelling the effects of precipitation and temperature on malaria incidence in coastal and western Kenya.Malaria journal · 2025Article
- Comparison of unmanned aerial vehicle imaging to ground truth walkthroughs for identifying and classifying trash sites serving as potential Aedes aegypti breeding grounds.Parasites & vectors · 2025Article
- Understanding the factors contributing to dengue virus and chikungunya virus seropositivity and seroconversion among children in Kenya.PLoS neglected tropical diseases · 2024Article
- Seroprevalence of Arboviruses in a Malaria Hyperendemic Area in Southern Mali.The American journal of tropical medicine and hygiene · 2024Article
- Acute febrile illness in Kenya: Clinical characteristics and pathogens detected among patients hospitalized with fever, 2017-2019.PloS one · 2024Article
- Current Epidemiological Status of Chikungunya Virus Infection in East Africa: A Systematic Review and Meta-Analysis.Journal of tropical medicine · 2024Review
- Seroprevalence of Dengue and Chikungunya Virus Infections in Children Living in Sub-Saharan Africa: Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Chikungunya outbreak in Africa: a review of the literature.Annals of medicine and surgery (2012) · 2023Article
- Seroprevalence of viral and bacterial pathogens among malaria patients in an endemic area of southern Venezuela.Infectious diseases of poverty · 2023Article
- Serological and molecular evidence of chikungunya virus infection among febrile outpatients seeking healthcare in Northern Malawi.Infection ecology & epidemiology · 2023Article
- Molecular screening reveals non-uniform malaria transmission in western Kenya and absence of Rickettsia africae and selected arboviruses in hospital patients.Malaria journal · 2022Article
- Incidence of chikungunya virus infections among Kenyan children with neurological disease, 2014-2018: A cohort study.PLoS medicine · 2022Article
- High Frequency of Antibiotic Prescription in Children With Undifferentiated Febrile Illness in Kenya.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Prevalence of Malaria and Chikungunya Co-Infection in Febrile Patients: A Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2021Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundIn sub-Saharan Africa, malaria is frequently overdiagnosed as the cause of an undifferentiated febrile illness, whereas arboviral illnesses are presumed to be underdiagnosed.
methodsSera from 385 febrile Kenyan children, who presented to 1 of 4 clinical sites, were tested using microscopy and real-time molecular assays for dengue virus (DENV), chikungunya virus (CHIKV), malaria, and
resultsMalaria was the primary clinical diagnosis for 254 patients, and an arboviral infection (DENV or CHIKV) was the primary diagnosis for 93 patients. In total, 158 patients (41.0%) had malaria and 32 patients (8.3%) had CHIKV infections. Compared with real-time polymerase chain reaction, microscopy demonstrated a percent positive agreement of 49.7%. The percentage of malaria cases detected by microscopy varied significantly between clinical sites. Arboviral infections were the clinical diagnosis for patients on the Indian Ocean coast (91 of 238, 38.2%) significantly more often than patients in the Lake Victoria region (2 of 145, 1.4%;
conclusionsThe clinical diagnosis of patients with an acute febrile illness, even when aided by microscopy, remains inaccurate in malaria-endemic areas, contributing to inappropriate management decisions.
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