Evidence map›Paper›PMID 28702345›Full record

ArticleNeuroImage. Clinical2017

Hierarchical disruption in the Bayesian brain: Focal epilepsy and brain networks.

Amir Omidvarnia, Mangor Pedersen, Richard E Rosch, Karl J Friston, Graeme D Jackson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The Thalamus as a Blackboard for Perception and Planning.Frontiers in behavioral neuroscience · 2021
    Article
  2. Minds and Brains, Sleep and Psychiatry.Psychiatric research and clinical practice · 2021
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amir OmidvarniaThe Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Austin Campus, Heidelberg, Victoria, Australia. Electronic address: a.omidvarnia@brain.org.au.
Mangor PedersenThe Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Austin Campus, Heidelberg, Victoria, Australia.
Richard E RoschThe Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK.
Karl J FristonThe Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK.
Graeme D JacksonThe Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Austin Campus, Heidelberg, Victoria, Australia; Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.

Funding

Wellcome TrustWellcome Trust 088130/Z/09/ZWellcome Trust 106556/Z/14/Z
6 · The paper itself

Abstract

In this opinion paper, we describe a combined view of functional and effective brain connectivity along with the free-energy principle for investigating persistent disruptions in brain networks of patients with focal epilepsy. These changes are likely reflected in effective connectivity along the cortical hierarchy and construct the basis of increased local functional connectivity in focal epilepsy. We propose a testable framework based on dynamic causal modelling and functional connectivity analysis with the capacity of explaining commonly observed connectivity changes during interictal periods. We then hypothesise their possible relation with disrupted free-energy minimisation in the Bayesian brain. This may offer a new approach for neuroimaging to specifically develop and address hypotheses regarding the network pathomechanisms underlying epileptic phenotypes.

Indexed as

Models, NeurologicalBayes TheoremBrainEpilepsies, PartialHumansNeural PathwaysBayesian inferenceEffective connectivityFocal epilepsyFree-energy principleFunctional connectivityPredictive coding

Identifiers

PMID28702345
PMCPMC5486238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.