ArticleJournal of systems and integrative neuroscience2017
Hemispheric Asymmetry of Development Due to Drug Exposure.
Article in Journal of systems and integrative neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Development of cerebral lateralization in children exposed to fetal antiseizure medications: A prospective cohort study at age 6 years.Epilepsia · 2026Article
- More widespread and rigid neuronal representation of reward expectation underlies impulsive choices.bioRxiv : the preprint server for biology · 2024Article
- Maternal ethanol consumption before paternal fertilization: Stimulation of hypocretin neurogenesis and ethanol intake in zebrafish offspring.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Embryonic Ethanol Exposure Affects the Early Development, Migration, and Location of Hypocretin/Orexin Neurons in Zebrafish.Alcoholism, clinical and experimental research · 2019Article
- Differential Effects of Addictive Drugs on Sleep and Sleep Stages.Journal of addiction research (OPAST Group) · 2019Article
- Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study.Developmental neuroscience · 2019Article
- Differential Activation of the Left and Right Cerebral Hemispheres of Individuals Who Use or are Dependent on Drugs of Abuse.Journal of drug abuse · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
backgroundA previous survey of the literature of fMRI brain activation for two risk factors, impulsivity and craving, for addiction were lateralized to the right and left hemispheres respectively. Most articles reported these findings without consideration of how lateral asymmetries might be relevant to understanding the underlying factors leading to addiction.
objectiveThe current survey is intended to extend these observations by demonstrating hemispheric asymmetry of development due to pre-natal or adolescent/adult exposure to drugs of abuse.
methodArticles that reported either pre-natal or adolescent/adult exposure to drugs of abuse were collected and the hemisphere of the affected structures was tabulated to determine if, and which, drugs affected more structures in one hemisphere or the other or both together.
resultsSome drugs, notably cocaine and alcohol, differentially affected left or right hemisphere structures which significantly differed depending on whether individuals were exposed prenatally or as an adolescent/adult. Cocaine tended to affect more left hemisphere structures when exposed prenatally and significantly affected more in the right when exposed as adults. Alcohol had the reverse pattern. The difference in patterns of effect between pre-natal or adult exposure was significant for both.
conclusionThe results in this survey demonstrate that some drugs of abuse appear to have a right/left differential effect on structures of the brain. Further investigation into the reasons for this asymmetry may provide new insights into underlying factors of drug-seeking and addiction.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.