Evidence map›Paper›PMID 28702212›Full record

ArticleObesity science & practice2017

Obesity, arterial function and arterial structure - a systematic review and meta-analysis.

J Y A Ne, T Y Cai, D S Celermajer, I D Caterson, T Gill, C M Y Lee, M R Skilton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity science & practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. Vascular function: a key player in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J Y A NeBoden Institute of Obesity, Nutrition, Exercise and Eating Disorders University of Sydney Australia.
T Y CaiBoden Institute of Obesity, Nutrition, Exercise and Eating Disorders University of Sydney Australia.
D S CelermajerSydney Medical School University of Sydney Australia.
I D CatersonBoden Institute of Obesity, Nutrition, Exercise and Eating Disorders University of Sydney Australia.
T GillBoden Institute of Obesity, Nutrition, Exercise and Eating Disorders University of Sydney Australia.
C M Y LeeBoden Institute of Obesity, Nutrition, Exercise and Eating Disorders University of Sydney Australia.
M R SkiltonBoden Institute of Obesity, Nutrition, Exercise and Eating Disorders University of Sydney Australia.ORCID 0000-0003-2793-2388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveObesity is an established risk factor for cardiovascular disease. The mechanisms by which obesity affects cardiovascular risk have not been fully elucidated. This paper reports a comprehensive systematic review and meta-analysis on obesity and two key aspects of vascular health using gold-standard non-invasive measures - arterial endothelial function (brachial flow-mediated dilatation) and subclinical atherosclerosis (carotid intima-media thickness).

methodsElectronic searches for 'Obesity and flow-mediated dilatation' and 'Obesity and intima-media thickness' were performed using Ovid Medline and Embase databases. A meta-analysis was undertaken for brachial flow-mediated dilatation and carotid intima-media thickness to obtain pooled estimates for adults with obesity and those with healthy weight.

resultsOf the 5,810 articles retrieved, 19 studies on flow-mediated dilatation and 19 studies on intima-media thickness were included. Meta-analysis demonstrated that obesity was associated with lower flow-mediated dilatation (-1.92 % [95% CI -2.92, -0.92],

conclusionsObesity is associated with poorer arterial endothelial function and increased subclinical atherosclerosis, consistent with these aspects of vascular health at least partially contributing to the increased risk of cardiovascular events in adults with obesity. These estimated effect sizes will enable vascular health benefits in response to weight loss treatment to be put in greater perspective, both in the research setting and potentially also clinical practice.

Indexed as

Atherosclerosisendothelial functionmeta‐analysisobesity

Identifiers

PMID28702212
PMCPMC5478805

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.