Evidence map›Paper›PMID 28702143›Full record

ArticleIranian journal of basic medical sciences2017

CXCR4 expression is associated with time-course permanent and temporary myocardial infarction in rats.

Ali Asghar Kiani, Fereshteh Babaei, Mehrnoosh Sedighi, Azam Soleimani, Kolsum Ahmadi, Somayeh Shahrokhi, Khatereh Anbari, Afshin Nazari

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In one paragraph

Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ali Asghar KianiRazi Herbal Medicines Research Center and School of Allied Medical Sciences, Department of Hematology and Blood Transfusion, Lorestan University of Medical Sciences, Khorramabad, Iran.
Fereshteh BabaeiStudent Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mehrnoosh SedighiStudent Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Azam SoleimaniDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Kolsum AhmadiRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Somayeh ShahrokhiDepartment of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Khatereh AnbariDepartment of Social Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Afshin NazariRazi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Lorestan University of Medical Sciences · IRIslamic Azad University, Science and Research Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesExperimental myocardial infarction triggers secretion of Stromal cell-derived factor1 and lead to increase in the expression of its receptor "CXCR4" on the surface of various cells. The aim of this study was to evaluate the expression pattern of CXCR4 in peripheral blood cells following time-course permanent and temporary ischemia in rats. MATERIALS AND

methodsFourteen male Wistar rats were divided into two groups of seven and were placed under permanent and transient ischemia. Peripheral blood mononuclear cells were isolated at different time points, RNAs extracted and applied to qRT-PCR analysis of the CXCR4 gene.

resultsBased on repeated measures analysis of variance, the differences in the expression levels of the gene in each of the groups were statistically significant over time (the effect of time) (

conclusionCXCR4 is modulated in an induced ischemia context implying a possible association with myocardial infarction. Checking of CXCR4 expression in the ischemic changes shows that damage to the heart tissue trigger the secretion of inflammatory chemokine SDF, Followed by it CXCR4 expression in blood cells. These observations suggest that changes in the expression of CXCR4 may be considered a valuable marker for monitoring myocardial infarction.

Indexed as

CXCR4 gene expressionPermanent cardiac-ischemiaTemporary cardiac-ischemiaTime-course

Identifiers

PMID28702143
PMCPMC5501928
OpenAlexW2726961002

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.