Evidence map›Paper›PMID 28702080›Full record

ArticleJournal of biological engineering2017

Investigation of poly(γ-glutamic acid) production via online determination of viscosity and oxygen transfer rate in shake flasks.

Lena Regestein Née Meissner, Julia Arndt, Thomas G Palmen, Tim Jestel, Hitoshi Mitsunaga, Eiichiro Fukusaki, Jochen Büchs

Abstract read
In one paragraph

Article in Journal of biological engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  5. Construction of an engineeredFrontiers in microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lena Regestein Née MeissnerAVT - Biochemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.ORCID 0000-0003-1394-2745
Julia ArndtAVT - Biochemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Thomas G PalmenAVT - Biochemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Tim JestelAVT - Enzyme Process Technology, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Hitoshi MitsunagaDepartment of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan.
Eiichiro FukusakiDepartment of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan.
Jochen BüchsAVT - Biochemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoly(γ-glutamic acid) (γ-PGA) is a biopolymer with many useful properties making it applicable for instance in food and skin care industries, in wastewater treatment, in biodegradable plastics or in the pharmaceutical industry. γ-PGA is usually produced microbially by different

resultsTwo different

conclusionsThe combination of the volumetric power input and the OTR allows for an easy and reliable investigation of new strains, cultivation conditions and medium compositions for their potential in γ-PGA production. The power input signal and the derived online viscosity directly reflect changes in γ-PGA molecular weight and concentration, respectively, due to different cultivation conditions or production strains.

Indexed as

Bacillus licheniformisEffective viscosityOnline volumetric power inputShake flask

Identifiers

PMID28702080
PMCPMC5506581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.