Evidence map›Paper›PMID 28702031›Full record

ArticleFrontiers in immunology2017

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance.

Eirini Nikolouli, Matthias Hardtke-Wolenski, Martin Hapke, Michael Beckstette, Robert Geffers, Stefan Floess, Elmar Jaeckel, Jochen Huehn

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

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  13. Regulatory T Cells-Related Genes Are under DNA Methylation Influence.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eirini NikolouliDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Matthias Hardtke-WolenskiDepartment Gastroenterology, Hepatology, Endocrinology, Hannover Medical School, Hannover, Germany.
Martin HapkeDepartment Gastroenterology, Hepatology, Endocrinology, Hannover Medical School, Hannover, Germany.
Michael BeckstetteDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Robert GeffersGenome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Stefan FloessDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Elmar JaeckelDepartment Gastroenterology, Hepatology, Endocrinology, Hannover Medical School, Hannover, Germany.
Jochen HuehnDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Helmholtz Centre for Infection Research · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T cells (Tregs) are critical for the maintenance of immune homeostasis and self-tolerance and can be therapeutically used for prevention of unwanted immune responses such as allotransplant rejection. Tregs are characterized by expression of the transcription factor Foxp3, and recent work suggests that epigenetic imprinting of

Indexed as

allo-iTregsdemethylationFoxp3transplantationvitamin C

Identifiers

PMID28702031
PMCPMC5487376
OpenAlexW2731213272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.