Evidence map›Paper›PMID 28702003›Full record

ArticleFrontiers in microbiology2017

Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple Sclerosis and Their Improvement with Ketogenic Diet.

Alexander Swidsinski, Yvonne Dörffel, Vera Loening-Baucke, Christoph Gille, Önder Göktas, Anne Reißhauer, Jürgen Neuhaus, Karsten-Henrich Weylandt, Alexander Guschin, Markus Bock

2 registry-linked trialsAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 97 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01538355 nacompletednot on this map

A Randomised Controlled Pilot Study to Compare the Effects of Prolonged Fasting and Ketogenic Low Glycemic Load Treatment on Health Related Quality of Life in Relapsing-remitting Multiple Sclerosis.

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2012 to 2020Enrolled48ConditionsRelapsing-Remitting Multiple SclerosisArmsProlonged Fasting, Ketogenic low glycemic load treatment, Control diet
NCT05119010 naterminatednot on this mapstarted 2023, after this paper: background citation

A Pilot Study Evaluating a Ketogenic Diet Concomitant to Nivolumab and Ipilimumab in Patients With Metastatic Renal Cell Carcinoma

TypeinterventionalSponsorGustave Roussy, Cancer Campus, Grand ParisRan2023 to 2024Enrolled3ConditionsMetastatic Renal Cell CarcinomaArmsContinuous ketogenic diet, Discontinuous ketogenic diet, beta-hydroxybutyrate (BHB) supplementation
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Review
  15. Article
  16. Review
  17. Ketogenic diet and Parkinson's disease.Frontiers in molecular neuroscience · 2026
    Review
  18. Review
  19. Review
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander SwidsinskiLaboratory for Molecular Genetics, Polymicrobial Infections and Biofilms, Section of Gastroenterology and Hepatology, Department of Medicine, Charité Universitätsmedizin BerlinBerlin, Germany.
Yvonne DörffelOutpatient Clinic, Charité Universitätsmedizin BerlinBerlin, Germany.
Vera Loening-BauckeLaboratory for Molecular Genetics, Polymicrobial Infections and Biofilms, Section of Gastroenterology and Hepatology, Department of Medicine, Charité Universitätsmedizin BerlinBerlin, Germany.
Christoph GilleLaboratory for Molecular Genetics, Polymicrobial Infections and Biofilms, Section of Gastroenterology and Hepatology, Department of Medicine, Charité Universitätsmedizin BerlinBerlin, Germany.
Önder GöktasLaboratory for Molecular Genetics, Polymicrobial Infections and Biofilms, Section of Gastroenterology and Hepatology, Department of Medicine, Charité Universitätsmedizin BerlinBerlin, Germany.
Anne ReißhauerLaboratory for Molecular Genetics, Polymicrobial Infections and Biofilms, Section of Gastroenterology and Hepatology, Department of Medicine, Charité Universitätsmedizin BerlinBerlin, Germany.
Jürgen NeuhausFaculty of Veterinary Medicine, Centre for Infectious Diseases, University of LeipzigLeipzig, Germany.
Karsten-Henrich WeylandtCharité Universitätsmedizin Berlin, Campus Virchow, Gastroenterology BerlinBerlin, Germany.
Alexander GuschinLaboratory of Molecular Diagnostics, Russian Research Center for Molecular Diagnostics and Therapy, Central Research InstituteMoscow, Russia.
Markus BockExperimental and Clinical Research Center, A Joint Cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular MedicineBerlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biofermentationcolonic microbiotaFISHketogenic dietmultiple sclerosis

Identifiers

PMID28702003
PMCPMC5488402

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.