ReviewFrontiers in pharmacology2017
Therapeutic Properties of Bioactive Compounds from Different Honeybee Products.
Review in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
178 citing papers in PubMed, 3 syntheses or guidelines pooled it, 446 citations in OpenAlex.
- Pharmacovigilance and toxicological risks associated with apitherapeutic products: a systematic overview.Archives of toxicology · 2026Pooled it
- Dosage exploration of the effects of honey and its derivatives on cardiometabolic outcomes: an overview of systematic reviews and GRADE-assessed updated meta-analysis.Nutrition & diabetes · 2025Pooled it
- Application of Propolis in Protecting Skeletal and Periodontal Health-A Systematic Review.Molecules (Basel, Switzerland) · 2021Pooled it
- Therapeutic Effects of Propolis Supplementation on the Inflammatory State, Oxidative Stress, and Uremic Toxins in dialysis Patients: A Systematic Review.Food science & nutrition · 2026Review
- Article
- Chemical Markers and Bioactivity of Algerian Royal Jelly: Influence of Bee Subspecies, Geography, and Lyophilization.Chemistry & biodiversity · 2026Article
- Application of Honey Dressing in the Management of Postoperative Wounds, Ulcers, and Burns: A Systematic Review.Cureus · 2026Review
- Bee products as alternatives in the treatment of viral infections.Journal of the science of food and agriculture · 2026Review
- High-throughput phenotypic screening identifies the phytochemical melissic acid that mitigates SHED cellular senescence via the ADCY5/cAMP/CREB axis.Frontiers in pharmacology · 2026Article
- Review
- Ensuring the Safe Use of Bee Products: A Review of Allergic Risks and Management.International journal of molecular sciences · 2025Review
- Knowledge and Use of Bee Products in Lithuania.Nutrients · 2025Article
- Preliminary Characterization of Bulgarian Forest Honeys: Oak Honeydew and Coniferous Varieties.Foods (Basel, Switzerland) · 2025Article
- Therapeutic Bioactivity Exerted by theMolecules (Basel, Switzerland) · 2025Article
- Exploring the potential of hydro alcoholic crude extract of beeswax as antibacterial antifungal antiviral antiinflammatory and antioxidant agent.Scientific reports · 2025Article
- Ecological, Apicultural, and Therapeutic Value ofFoods (Basel, Switzerland) · 2025Review
- Molecular Networking-Guided Annotation of Flavonoid Glycosides fromInternational journal of molecular sciences · 2025Article
- Propolis-Loaded Niosomes for Dermopharmaceutic and Cosmetic Applications: Development, Stability, Safety, andACS pharmacology & translational science · 2025Article
- Innovations in Edible Packaging Films, Coatings, and Antimicrobial Agents for Applications in Food Industry.Comprehensive reviews in food science and food safety · 2025Review
- Natural Honey-Propolis Combinations with Health-Promoting Potential: Antibacterial Activity Against Foodborne Pathogens.Pharmaceuticals (Basel, Switzerland) · 2025Article
118 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.