Evidence map›Paper›PMID 28701947›Full record

ReviewFrontiers in aging neuroscience2017

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease.

Luxi Wang, Nian Xiong, Jinsha Huang, Shiyi Guo, Ling Liu, Chao Han, Guoxin Zhang, Haiyang Jiang, Kai Ma, Yun Xia and 4 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Vital nutrition: enhancing health in advanced Parkinson's disease with device-aided therapies.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Dietary Interventions in Parkinson's Disease.Journal of Parkinson's disease · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Luxi WangDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Nian XiongDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Jinsha HuangDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Shiyi GuoDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Ling LiuDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Chao HanDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Guoxin ZhangDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Haiyang JiangDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Kai MaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Yun XiaDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Xiaoyun XuDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Jie LiDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Jing Y LiuKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and TechnologyWuhan, China.
Tao WangDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Union Hospital · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose wearing off and unpredictable "on-off"). Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain. On the other hand, the protein-restricted diets including low-protein diet (LPD), protein-redistribution diet (PRD) and PRD with use of low-protein products can all improve the efficacy of levodopa in patients with motor fluctuations. However, it should be noted that protein-restricted diets may also contribute to several side effects, including dyskinesia, weight loss, and malnutrition (e.g., protein and calcium insufficiency). Together, protein-restricted diets are an effective approach to improve motor fluctuations in PD patients, while long-term adherence to these diets requires monitoring for side effects.

Indexed as

diet therapyfluctuationlevodopaParkinson's diseaseprotein

Identifiers

PMID28701947
PMCPMC5487390
OpenAlexW2724701816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.