Evidence map›Paper›PMID 28701927›Full record

ArticleFrontiers in cellular neuroscience2017

Activation of the CREB/

Daniela Gandolfi, Silvia Cerri, Jonathan Mapelli, Mariarosa Polimeni, Simona Tritto, Marie-Therese Fuzzati-Armentero, Albertino Bigiani, Fabio Blandini, Lisa Mapelli, Egidio D'Angelo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

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  19. Dioscin-Mediated Autophagy Alleviates MPPMolecules (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Daniela GandolfiNeurophysiology Unit, Department of Brain and Behavioral Sciences, University of PaviaPavia, Italy.
Silvia CerriLaboratory of Functional Neurochemistry, Center for Research in Neurodegenerative Diseases, Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IRCCS)Pavia, Italy.
Jonathan MapelliNeurophysiology Unit, Department of Brain and Behavioral Sciences, University of PaviaPavia, Italy.
Mariarosa PolimeniDepartment of Public Health, Experimental and Forensic Medicine, Human Anatomy Unit, University of PaviaPavia Italy.
Simona TrittoNeurophysiology Unit, Department of Brain and Behavioral Sciences, University of PaviaPavia, Italy.
Marie-Therese Fuzzati-ArmenteroLaboratory of Functional Neurochemistry, Center for Research in Neurodegenerative Diseases, Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IRCCS)Pavia, Italy.
Albertino BigianiDepartment of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio EmiliaModena, Italy.
Fabio BlandiniLaboratory of Functional Neurochemistry, Center for Research in Neurodegenerative Diseases, Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IRCCS)Pavia, Italy.
Lisa MapelliNeurophysiology Unit, Department of Brain and Behavioral Sciences, University of PaviaPavia, Italy.
Egidio D'AngeloNeurophysiology Unit, Department of Brain and Behavioral Sciences, University of PaviaPavia, Italy.
Fondazione Istituto Neurologico Nazionale Casimiro Mondino · ITUniversity of Pavia · ITEnrico Fermi Center for Study and Research · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The induction of long-term potentiation and depression (LTP and LTD) is thought to trigger gene expression and protein synthesis, leading to consolidation of synaptic and neuronal changes. However, while LTP and LTD have been proposed to play important roles for sensori-motor learning in the cerebellum granular layer, their association with these mechanisms remained unclear. Here, we have investigated phosphorylation of the cAMP-responsive element binding protein (CREB) and activation of the immediate early gene

Indexed as

cerebellumCREBgene expressionlong-term plasticityNMDARs

Identifiers

PMID28701927
PMCPMC5487453
OpenAlexW2727549996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.