ReviewFrontiers in cellular neuroscience2017
Cell Polarity in Cerebral Cortex Development-Cellular Architecture Shaped by Biochemical Networks.
Review in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Coordinated neural progenitor adaptations contribute to primate neocortical downscaling.Science advances · 2026Article
- Expression of Dystrophin Dp71 Splice Variants Is Temporally Regulated During Rodent Brain Development.Molecular neurobiology · 2024Article
- Purinosomes and Purine Metabolism in Mammalian Neural Development: A Review.Acta histochemica et cytochemica · 2024Review
- Balloon cells in malformations of cortical development: friends or foes?Acta epileptologica · 2024Review
- Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.PLoS genetics · 2022Article
- Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration.Oxford open neuroscience · 2022Article
- Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development.iScience · 2021Article
- Inheritance and flexibility of cell polarity: a clue for understanding human brain development and evolution.Development (Cambridge, England) · 2021Article
- In vitro reconstitution reveals phosphoinositides as cargo-release factors and activators of the ARF6 GAP ADAP1.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- From Cell States to Cell Fates: How Cell Proliferation and Neuronal Differentiation Are Coordinated During Embryonic Development.Frontiers in neuroscience · 2021Review
- Neuroregeneration and functional recovery after stroke: advancing neural stem cell therapy toward clinical application.Neural regeneration research · 2021Article
- Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke.Neuropsychiatric disease and treatment · 2021Review
- Roots of the Malformations of Cortical Development in the Cell Biology of Neural Progenitor Cells.Frontiers in neuroscience · 2021Review
- Microtubules and motor proteins support zebrafish neuronal migration by directing cargo.The Journal of cell biology · 2020Article
- mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex.eLife · 2020Article
- Review
- Nwd1 Regulates Neuronal Differentiation and Migration through Purinosome Formation in the Developing Cerebral Cortex.iScience · 2020Article
- Non-Cell-Autonomous Mechanisms in Radial Projection Neuron Migration in the Developing Cerebral Cortex.Frontiers in cell and developmental biology · 2020Review
- Adherens Junctions: Guardians of Cortical Development.Frontiers in cell and developmental biology · 2020Review
- How Do Electric Fields Coordinate Neuronal Migration and Maturation in the Developing Cortex?Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The human cerebral cortex is the seat of our cognitive abilities and composed of an extraordinary number of neurons, organized in six distinct layers. The establishment of specific morphological and physiological features in individual neurons needs to be regulated with high precision. Impairments in the sequential developmental programs instructing corticogenesis lead to alterations in the cortical cytoarchitecture which is thought to represent the major underlying cause for several neurological disorders including neurodevelopmental and psychiatric diseases. In this review article we discuss the role of cell polarity at sequential stages during cortex development. We first provide an overview of morphological cell polarity features in cortical neural stem cells and newly-born postmitotic neurons. We then synthesize a conceptual molecular and biochemical framework how cell polarity is established at the cellular level through a break in symmetry in nascent cortical projection neurons. Lastly we provide a perspective how the molecular mechanisms applying to single cells could be probed and integrated in an
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Registered trials
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