ArticleFrontiers in molecular neuroscience2017
Striatal Transcriptome and Interactome Analysis of
Article in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome.iScience · 2026Article
- PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior.Nature communications · 2025Article
- The emerging roles of Shank3 in cardiac function and dysfunction.Frontiers in cell and developmental biology · 2023Review
- Transcriptomic analysis in the striatum reveals the involvement of Nurr1 in the social behavior of prenatally valproic acid-exposed male mice.Translational psychiatry · 2022Article
- SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system.Cellular and molecular life sciences : CMLS · 2022Article
- Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states.Cell reports · 2021Article
- Proteome Analysis of PC12 Cells Reveals Alterations in Translation Regulation and Actin Signaling Induced by Clozapine.Neurochemical research · 2021Article
- Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice.Molecular brain · 2021Article
- Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type andFrontiers in molecular neuroscience · 2021Article
- Proteomics and Metabolomics Approaches towards a Functional Insight onto AUTISM Spectrum Disorders: Phenotype Stratification and Biomarker Discovery.International journal of molecular sciences · 2020Review
- Protein Translation and Psychiatric Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020Review
- The Neomycin Resistance Cassette in the Targeted Allele ofFrontiers in molecular neuroscience · 2020Article
- Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice.Scientific reports · 2019Article
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- Unexpected Compensatory Increase inFrontiers in molecular neuroscience · 2019Article
- Transcriptome analyses suggest minimal effects of Shank3 dosage on directional gene expression changes in the mouse striatum.Animal cells and systems · 2019Article
- Transcriptome analysis of Shank3-overexpressing mice reveals unique molecular changes in the hypothalamus.Molecular brain · 2018Article
- Characterization of Parkinson's disease-related pathogenic TMEM230 mutants.Animal cells and systems · 2018Article
- GABA Neuronal Deletion ofFrontiers in cellular neuroscience · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mania causes symptoms of hyperactivity, impulsivity, elevated mood, reduced anxiety and decreased need for sleep, which suggests that the dysfunction of the striatum, a critical component of the brain motor and reward system, can be causally associated with mania. However, detailed molecular pathophysiology underlying the striatal dysfunction in mania remains largely unknown. In this study, we aimed to identify the molecular pathways showing alterations in the striatum of SH3 and multiple ankyrin repeat domains 3 (Shank3)-overexpressing transgenic (TG) mice that display manic-like behaviors. The results of transcriptome analysis suggested that mammalian target of rapamycin complex 1 (mTORC1) signaling may be the primary molecular signature altered in the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.