ArticleScientific reports2017
Terahertz Spectroscopic Diagnosis of Myelin Deficit Brain in Mice and Rhesus Monkey with Chemometric Techniques.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Terahertz attenuated total reflection imaging of fresh brain glioma based on a solid immersion lens.Biomedical optics express · 2026Article
- A new horizon for neuroscience: terahertz biotechnology in brain research.Neural regeneration research · 2025Article
- Biomedical application of terahertz imaging technology: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Spatial and spectral characteristics in realizations of broadband terahertz spectroscopy on a subwavelength scale.Scientific reports · 2023Article
- Review
- Triage ofBiomedical optics express · 2023Article
- Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2022Article
- Supervised machine learning for automatic classification of in vivo scald and contact burn injuries using the terahertz Portable Handheld Spectral Reflection (PHASR) Scanner.Scientific reports · 2022Article
- Advances of terahertz technology in neuroscience: Current status and a future perspective.iScience · 2021Review
- Terahertz dielectric spectroscopy and solid immersion microscopy ofBiomedical optics express · 2021Article
- Non-contact terahertz spectroscopic measurement of the intraocular pressure through corneal hydration mapping.Biomedical optics express · 2021Article
- Terahertz dielectric spectroscopy of human brain gliomas and intact tissuesBiomedical optics express · 2021Article
- A Review of Feasible Applications of THz Waves in Medical Diagnostics and Treatments.Journal of lasers in medical sciences · 2021Review
- Ghost spintronic THz-emitter-array microscope.Light, science & applications · 2020Article
- Label-free monitoring of cell death induced by oxidative stress in living human cells using terahertz ATR spectroscopy.Biomedical optics express · 2018Article
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Authors and funding
12 authors.
Funding
Abstract
While myelin deficit of the central nervous system leads to several severe diseases, the definitive diagnostic means are lacking. We proposed and performed terahertz time-domain spectroscopy (THz-TDS) combined with chemometric techniques to discriminate and evaluate the severity of myelin deficit in mouse and rhesus monkey brains. The THz refractive index and absorption coefficient of paraffin-embedded brain tissues from both normal and mutant dysmyelinating mice are shown. Principal component analysis of time-domain THz signal (PCA-tdTHz) and absorption-refractive index relation of THz spectrum identified myelin deficit without exogenous labeling or any pretreatment. Further, with the established PCA-tdTHz, we evaluated the severity of myelin deficit lesions in rhesus monkey brain induced by experimental autoimmune encephalomyelitis, which is the most-studied animal model of multiple sclerosis. The results well matched the pathological analysis, indicating that PCA-tdTHz is a quick, powerful, evolving tool for identification and evaluation myelin deficit in preclinical animals and potentially in para-clinical human biopsy.
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