ArticleScientific reports2017
Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers.Journal Of Elasticity · 2025Article
- Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells.Scientific reports · 2021Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Control of cell colony growth by contact inhibition.Scientific reports · 2020Article
- Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contact inhibition plays a crucial role in cell motility, wound healing, and tumour formation. By mimicking the mechanical motion of cells crawling on a substrate, we constructed a minimal model of migrating cells that naturally gives rise to contact inhibition of locomotion (CIL). The model cell consists of two disks, a front disk (a pseudopod) and a back disk (cell body), which are connected by a finite extensible spring. Despite the simplicity of the model, the collective behaviour of the cells is highly non-trivial and depends on both the shape of the cells and whether CIL is enabled. Cells with a small front disk (i.e., a narrow pseudopod) form immobile colonies. In contrast, cells with a large front disk (e.g., a lamellipodium) exhibit coherent migration without any explicit alignment mechanism in the model. This result suggests that crawling cells often exhibit broad fronts because this helps facilitate alignment. After increasing the density, the cells develop density waves that propagate against the direction of cell migration and finally stop at higher densities.
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Registered trials
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