ArticleScientific reports2017
Genotype by random environmental interactions gives an advantage to non-favored minor alleles.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- The effect of the fitness gradient on fixation probability.Nature communications · 2026Article
- Extinction scenarios in evolutionary processes: a multinomial Wright-Fisher approach.Journal of mathematical biology · 2023Article
- The role of evolutionary game theory in spatial and non-spatial models of the survival of cooperation in cancer: a review.Journal of the Royal Society, Interface · 2022Review
- The network structure affects the fixation probability when it couples to the birth-death dynamics in finite population.PLoS computational biology · 2021Article
- The Moran process on 2-chromatic graphs.PLoS computational biology · 2020Article
- Environmental spatial and temporal variability and its role in non-favoured mutant dynamics.Journal of the Royal Society, Interface · 2019Article
- Environmental fitness heterogeneity in the Moran process.Royal Society open science · 2019Article
- The effect of spatial randomness on the average fixation time of mutants.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fixation probability, the probability that the frequency of a newly arising mutation in a population will eventually reach unity, is a fundamental quantity in evolutionary genetics. Here we use a number of models (several versions of the Moran model and the haploid Wright-Fisher model) to examine fixation probabilities for a constant size population where the fitness is a random function of both allelic state and spatial position, despite neither allele being favored on average. The concept of fitness varying with respect to both genotype and environment is important in models of cancer initiation and progression, bacterial dynamics, and drug resistance. Under our model spatial heterogeneity redefines the notion of neutrality for a newly arising mutation, as such mutations fix at a higher rate than that predicted under neutrality. The increased fixation probability appears to be due to rare alleles having an advantage. The magnitude of this effect can be large, and is an increasing function of the spatial variance and skew in fitness. The effect is largest when the fitness values of the mutants and wild types are anti-correlated across environments. We discuss results for both a spatial ring geometry of cells (such as that of a colonic crypt), a 2D lattice and a mass-action (complete graph) arrangement.
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