ArticleScientific reports2017
Beyond the Debye length in high ionic strength solution: direct protein detection with field-effect transistors (FETs) in human serum.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Miniaturization of Aptasensors in Organic Electrochemical Transistors for Sensitivity Enhancement.Analytical chemistry · 2026Article
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- Ultrasensitive Detection of Neurofilament Light in Plasma Using F(Ab')Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Practical Applications of 2D Material FET Biosensors: Functionalization Strategies and Detection Performance.Biosensors · 2026Review
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- Modulating Electrostatic Interactions to Control the Analyte Transport in Nanochannels.ACS applied materials & interfaces · 2025Article
- Numerical Analysis of Microfluidic Motors Actuated by Reconfigurable Induced-Charge Electro-Osmotic Whirling Flow.Micromachines · 2025Article
- Capacitive Sensors for Label-Free Detection in High-Ionic-Strength Bodily Fluids: A Review.Biosensors · 2025Review
- Article
- Biosensing approaches in body fluids using extended-gate-type organic field-effect transistor enzymatic sensors.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Advanced Materials for Biological Field-Effect Transistors (Bio-FETs) in Precision Healthcare and Biosensing.Advanced healthcare materials · 2025Review
- Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing.Biosensors · 2025Article
- A hybrid OTFT-SPR system for simultaneous electronic and optical sensing.Scientific reports · 2025Article
- Detection of IgG Antibodies Against COVID-19 N-Protein by Hybrid Graphene-Nanorod Sensor.Biosensors · 2025Article
- A portable and cost-effective system for electronic nucleic acid mass measurement.Scientific reports · 2025Article
- Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation.Nature nanotechnology · 2025Article
- Label-free electronic detection of peptide post-translational modification with functional enzyme-driven assay at the physical limit.Cell reports. Physical science · 2024Article
- Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors.Biosensors · 2024Article
- Determining intrinsic potentials and validating optical binding forces between colloidal particles using optical tweezers.Nature communications · 2024Article
- Numerical investigation of a graphene-on-semiconductor device for optical monitoring of cell electrophysiology.iScience · 2024Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) are used to directly detect proteins, including HIV-1 RT, CEA, NT-proBNP and CRP, in 1X PBS (with 1%BSA) or human sera. The samples do not need any dilution or washing process to reduce the ionic strength. The sensor shows high sensitivity and the detection takes only 5 minutes. The designs of the sensor, the methodology of the measurement, and the working mechanism of the sensor are discussed and investigated. A theoretical model is proposed based on the finding of the experiments. This sensor is promising for point-of-care, home healthcare, and mobile diagnostic device.
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