ArticleScientific reports2017
Intraoperative frozen section can be reduced in thyroid nodules classified as Bethesda categories V and VI.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- [Frozen section in oncologic endocrine surgery].Chirurgie (Heidelberg, Germany) · 2025Pooled it
- Machine learning model for differentiating malignant from benign thyroid nodules based on the thyroid function data.BMJ open · 2025Article
- Integrated intraoperative predictive model for malignancy risk assessment of thyroid nodules with atypia of undetermined significance cytology.Scientific reports · 2025Article
- A study of machine learning models for rapid intraoperative diagnosis of thyroid nodules for clinical practice in China.Cancer medicine · 2024Article
- Combined fine-needle aspiration and selective intraoperative frozen section to optimize prediction of malignant thyroid nodules: A retrospective cohort study of more than 3000 patients.Frontiers in endocrinology · 2023Article
- The Role of Frozen Section Examination in Thyroid Surgery.Sisli Etfal Hastanesi tip bulteni · 2023Review
- Intraoperative frozen section performance for thyroid cancer diagnosis.Archives of endocrinology and metabolism · 2022Article
- Targeted use of intraoperative frozen-section analysis lowers the frequency of completion thyroidectomy.BJS open · 2021Article
- Patients with III and IV category of the Bethesda System under levothyroxine non-suppressive therapy have a lower rate of thyroid malignancy.Scientific reports · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Intraoperative frozen section (FS) can be reduced during thyroid lobectomy according to the results of fine needle aspiration (FNA). We evaluated the role of intraoperative FS in thyroid nodules with different diagnostic categories of the Bethesda System for Reporting Thyroid Cytopathology by FNA. This retrospective study included 1,235 nodules collected via thyroidectomy with both preoperative FNA and intraoperative FS at the Second Affiliated Hospital of Zhejiang University School of Medicine, from January 2011 to January 2014. FNA cytological diagnosis was classified into six categories, based on the Bethesda system. The diagnostic findings of FNA cytology and FS histology were compared with the final histological results. 189 nodules were benign. The remainder were malignant. FS diagnosis was more accurate than FNA diagnosis for nodules classified as Bethesda Categories II, III, and IV (P < 0.05). However, the accuracy of FNA diagnosis in nodules assigned Bethesda Categories V and VI was significantly higher than that of FS (P < 0.05). FS appears be beneficial for thyroid nodules classified as Bethesda categories I through IV. FS may not be necessary in nodules diagnosed as Bethesda Categories V and VI.
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