ArticleJournal of neurophysiology2017
Basal tree complexity shapes functional pathways in the prefrontal cortex.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Review
- Common Microscale and Macroscale Principles of Connectivity in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Axonal Tree Morphology and Signal Propagation Dynamics Improve Interneuron Classification.Neuroinformatics · 2020Article
- Illuminating dendritic function with computational models.Nature reviews. Neuroscience · 2020Review
- Impaired Cortical Cytoarchitecture and Reduced Excitability of Deep-Layer Neurons in the Offspring of Diabetic Rats.Frontiers in cell and developmental biology · 2020Article
- The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism.Frontiers in psychiatry · 2019Article
- Patterns of Dendritic Basal Field Orientation of Pyramidal Neurons in the Rat Somatosensory Cortex.eNeuroArticle
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Authors and funding
3 authors.
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Abstract
While the morphology of basal dendritic trees in cortical pyramidal neurons varies, the functional implications of this diversity are just starting to emerge. In layer 5 pyramidal neurons of the prefrontal cortex, for example, increased basal tree complexity determines the recruitment of these neurons into functional circuits. Here, we use a modeling approach to investigate whether and how the morphology of the basal tree mediates the functional output of neurons. We implemented 57 basal tree morphologies of layer 5 prefrontal pyramidal neurons of the rat and identified morphological types that were characterized by different response features, forming distinct functional types. These types were robust to a wide range of manipulations (distribution of active ionic mechanisms, NMDA conductance, somatic and apical tree morphology, or the number of activated synapses) and supported different temporal coding schemes at both the single neuron and the microcircuit level. We predict that the basal tree morphological diversity among neurons of the same class mediates their segregation into distinct functional pathways. Extension of our approach/findings to other cortical areas and/or layers or under pathological conditions may provide a generalized role of the basal trees for neuronal function.
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