Evidence map›Paper›PMID 28701525›Full record

ArticlePhysiological reports2017

Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells.

Tinne C J Mertens, Anne M van der Does, Loes E Kistemaker, Dennis K Ninaber, Christian Taube, Pieter S Hiemstra

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Long-Term PMAnnals of the American Thoracic Society · 2025
    Pooled it
  2. Trial
  3. Article
  4. Frontiers in microbiology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Decreased Sputum Type-2 Gene Expression in COPD Current Smokers.International journal of chronic obstructive pulmonary disease · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Serial Sampling of the Small Airway Epithelium to Identify Persistent Smoking-dysregulated Genes.American journal of respiratory and critical care medicine · 2023
    Article
  13. Article
  14. A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis.American journal of respiratory cell and molecular biology · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tinne C J MertensDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands tinne.c.mertens@uth.tmc.edu.
Anne M van der DoesDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Loes E KistemakerDepartment of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
Dennis K NinaberDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Christian TaubeDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Pieter S HiemstraDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergic airways inflammation in asthma is characterized by an airway epithelial gene signature composed of

Indexed as

BronchiEpithelial CellsGene Expression RegulationHumansInterleukin-13SmokeTobacco ProductsTracheaTranscriptomeInterleukin-13SmokeAsthmainterleukin 13primary human epithelial cellsT helper 2whole cigarette smoke

Identifiers

PMID28701525
PMCPMC5506530
OpenAlexW2735855081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.