Trial reportPhysiological reports2017
Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation.
Trial report in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Effects of Exercise Training on Anabolic and Catabolic Hormones with Advanced Age: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Trial
- Effects of upper-body, lower-body, or combined resistance training on the ratio of follistatin and myostatin in middle-aged men.European journal of applied physiology · 2019Trial
- Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation.Physiological reports · 2017Trial
- Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential.Archives of pharmacal research · 2026Review
- Electrical pulse stimulation reflecting the episodic nature of real-life exercise modulates metabolic and secretory profile of primary human myotubes.FEBS open bio · 2026Article
- Effect of high-intensity interval training and resistance training on the follistatin and myostatin levels in gastrocnemius muscle of aged female rats.Biogerontology · 2025Article
- Acute endurance exercise modulates growth differentiation factor 11 in cerebrospinal fluid of healthy young adults.Frontiers in endocrinology · 2023Article
- Impact of high-intensity interval training on cardio-metabolic health outcomes and mitochondrial function in older adults: a review.Medicine and pharmacy reports · 2022Review
- Editorial: Exercise as a Countermeasure to Human Aging, Volume II.Frontiers in physiology · 2022Article
- Effect of Acute Ramadan Fasting on Muscle Function and Buffering System of Male Athletes.Healthcare (Basel, Switzerland) · 2021Article
- Effect of Various Exercise Regimens on Selected Exercise-Induced Cytokines in Healthy People.International journal of environmental research and public health · 2021Review
- Short-Term and Lifelong Exercise Training Lowers Inflammatory Mediators in Older Men.Frontiers in physiology · 2021Article
- Low-Intensity Exercise Routine for a Long Period of Time Prevents Osteosarcopenic Obesity in Sedentary Old Female Rats, by Decreasing Inflammation and Oxidative Stress and Increasing GDF-11.Oxidative medicine and cellular longevity · 2021Article
- Editorial: Exercise as a Countermeasure to Human Aging.Frontiers in physiology · 2020Article
- The Effect of Exercise on Glucoregulatory Hormones: A Countermeasure to Human Aging: Insights from a Comprehensive Review of the Literature.International journal of environmental research and public health · 2019Review
- Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise.The Journal of clinical endocrinology and metabolism · 2018Article
- Activin subfamily peptides predict chronological age in humans.Physiological reports · 2018Article
- Differing Effects of Younger and Older Human Plasma on C2C12 MyocytesFrontiers in physiology · 2018Article
- Short-Term Exercise Training Inconsistently Influences Basal Testosterone in Older Men: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males. Therefore, we investigated whether serum total myostatin, free myostatin, follistatin, and growth and differentiation factor 11 (GDF11) were altered following high-intensity interval training (HIIT) in a group of 13 lifelong sedentary (SED; 64 [6] years) and 11 lifelong exercising (LEX; 62 [6] years) older males. SED follistatin was moderately greater than LEX pre-HIIT (Cohen's
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.