Evidence map›Paper›PMID 28701495›Full record

ArticleNeurology2017

Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis.

Elisa Longinetti, Daniela Mariosa, Henrik Larsson, Weimin Ye, Caroline Ingre, Catarina Almqvist, Paul Lichtenstein, Fredrik Piehl, Fang Fang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. Psychiatric disorders in amyotrophic lateral sclerosis: a short note.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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  9. Identifying and Diagnosing TDP-43 Neurodegenerative Diseases in Psychiatry.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Review
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  16. Genetic analysis of ALS cases in the isolated island population of Malta.European journal of human genetics : EJHG · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Elisa LonginettiFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden. elisa.longinetti@ki.se.
Daniela MariosaFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Henrik LarssonFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Weimin YeFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Caroline IngreFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Catarina AlmqvistFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Paul LichtensteinFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Fredrik PiehlFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Fang FangFrom the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate risks of neurodegenerative and psychiatric diseases among patients with amyotrophic lateral sclerosis (ALS) and their families.

methodsWe conducted a register-based nested case-control study during 1990-2013 in Sweden to assess whether patients with ALS had higher risks of other neurodegenerative and psychiatric diseases before diagnosis. We included 3,648 patients with ALS and 36,480 age-, sex-, and county of birth-matched population controls. We further conducted a follow-up study of the cases and controls to assess the risks of other neurodegenerative and psychiatric diseases after ALS diagnosis. To assess the potential contribution of familial factors, we conducted similar studies for the relatives of patients with ALS and their controls.

resultsIndividuals with previous neurodegenerative or psychiatric diseases had a 49% increased risk of ALS (odds ratio 1.49, 95% confidence interval 1.35-1.66) compared to individuals without these diseases. After diagnosis, patients with ALS had increased risks of other neurodegenerative or psychiatric diseases (hazard ratio 2.90, 95% confidence interval 2.46-3.43) compared to individuals without ALS. The strongest associations were noted for frontotemporal dementia, Parkinson disease, other dementia, Alzheimer disease, neurotic disorders, depression, stress-related disorders, and drug abuse/dependence. First-degree relatives of patients with ALS had higher risk of neurodegenerative diseases, whereas only children of patients with ALS had higher risk of psychiatric disorders, compared to relatives of the controls.

conclusionsFamilial aggregation of ALS and other neurodegenerative diseases implies a shared etiopathogenesis among all neurodegenerative diseases. The increased risk of psychiatric disorders among patients with ALS and their children might be attributable to nonmotor symptoms of ALS and severe stress response toward the diagnosis.

Indexed as

FamilyGenetic Predisposition to DiseaseAgedAmyotrophic Lateral SclerosisCase-Control StudiesFemaleFollow-Up StudiesHumansMaleMental DisordersMiddle AgedOdds RatioProspective StudiesRegistriesSweden

Identifiers

PMID28701495
PMCPMC5562958
OpenAlexW2735980134

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.