ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Place and Grid Cells in a Loop: Implications for Memory Function and Spatial Coding.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A simple model of co-emergence of grid and place fields.bioRxiv : the preprint server for biology · 2026Article
- Article
- The Contribution of Spatially Tuned Brain Cells to Human Navigation Performance.KN - journal of cartography and geographic information · 2026Review
- Three types of remapping with linear decoders: A population-geometric perspective.PLoS computational biology · 2025Article
- Three types of remapping with linear decoders: a population-geometric perspective.bioRxiv : the preprint server for biology · 2025Article
- Relating sparse and predictive coding to divisive normalization.PLoS computational biology · 2025Article
- A spatial transformation-based CAN model for information integration within grid cell modules.Cognitive neurodynamics · 2024Article
- Modeling Grid Cell Distortions with a Grid Cell Calibration Mechanism.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model.Scientific reports · 2022Article
- Connectivity concepts in neuronal network modeling.PLoS computational biology · 2022Review
- Article
- The Role of Idiothetic Signals, Landmarks, and Conjunctive Representations in the Development of Place and Head-Direction Cells: A Self-Organizing Neural Network Model.Cerebral cortex communications · 2022Article
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
- A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease.PLoS computational biology · 2021Article
- Article
- Cognitive swarming in complex environments with attractor dynamics and oscillatory computing.Biological cybernetics · 2020Article
- Article
- Regulation of gamma-frequency oscillation by feedforward inhibition: A computational modeling study.Hippocampus · 2019Article
- Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex.The European journal of neuroscience · 2019Article
- Grid-like Neural Representations Support Olfactory Navigation of a Two-Dimensional Odor Space.Neuron · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Place cells in the hippocampus and grid cells in the medial entorhinal cortex have different codes for space. However, how one code relates to the other is ill understood. Based on the anatomy of the entorhinal-hippocampal circuitry, we constructed a model of place and grid cells organized in a loop to investigate their mutual influence in the establishment of their codes for space. Using computer simulations, we first replicated experiments in rats that measured place and grid cell activity in different environments, and then assessed which features of the model account for different phenomena observed in neurophysiological data, such as pattern completion and pattern separation, global and rate remapping of place cells, and realignment of grid cells. We found that (1) the interaction between grid and place cells converges quickly; (2) the spatial code of place cells does not require, but is altered by, grid cell input; (3) plasticity in sensory inputs to place cells is key for pattern completion but not pattern separation; (4) grid realignment can be explained in terms of place cell remapping as opposed to the other way around; (5) the switch between global and rate remapping is self-organized; and (6) grid cell input to place cells helps stabilize their code under noisy and/or inconsistent sensory input. We conclude that the hippocampus-entorhinal circuit uses the mutual interaction of place and grid cells to encode the surrounding environment and propose a theory on how such interdependence underlies the formation and use of the cognitive map.
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