Evidence map›Paper›PMID 28701395›Full record

ArticleJournal of virology2017

Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA Prime-Modified Vaccinia Virus Ankara Boost HIV-1 Vaccine Regimen.

Asli Bauer, Lilli Podola, Philipp Mann, Marco Missanga, Antelmo Haule, Lwitiho Sudi, Charlotta Nilsson, Bahati Kaluwa, Cornelia Lueer, Maria Mwakatima and 16 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 4 countries.

Asli BauerNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Lilli PodolaNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Philipp MannNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Marco MissangaNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Antelmo HauleNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Lwitiho SudiNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Charlotta NilssonPublic Health Agency of Sweden, Solna, Sweden.
Bahati KaluwaNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Cornelia LueerNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Maria MwakatimaNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Patricia J MunseriDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Leonard MabokoNIMR Mbeya Medical Research Center (MMRC), Mbeya, Tanzania.
Merlin L RobbUnited States Military HIV Research Program (MHRP), Bethesda, Maryland, USA.
Sodsai TovanabutraUnited States Military HIV Research Program (MHRP), Bethesda, Maryland, USA.
Gustavo KijakUnited States Military HIV Research Program (MHRP), Bethesda, Maryland, USA.
Mary MarovichUnited States Military HIV Research Program (MHRP), Bethesda, Maryland, USA.
Sheena McCormackMRC Clinical Trials Unit at UCL, London, United Kingdom.
Sarah JosephMRC Clinical Trials Unit at UCL, London, United Kingdom.
Eligius LyamuyaMuhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Britta WahrenDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Eric SandströmKarolinska Institute, Stockholm, Sweden.
Gunnel BiberfeldPublic Health Agency of Sweden, Solna, Sweden.
Michael HoelscherDivision of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany.
Muhammad BakariMuhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Arne KroidlDivision of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany.
Christof GeldmacherDivision of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany geldmacher@lrz.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DEKarolinska Institutet · SEMuhimbili University of Health and Allied Sciences · TZGerman Center for Infection Research · DEMRC Clinical Trials Unit at UCL · GBPublic Health Agency of Sweden · SEUniversity College London · GB

Funding

Medical Research Council MC_U122861400Medical Research Council MC_UU_12023/23Medical Research Council MRC_UU_12023/23
6 · The paper itself

Abstract

Prime-boost vaccination strategies against HIV-1 often include multiple variants for a given immunogen for better coverage of the extensive viral diversity. To study the immunologic effects of this approach, we characterized breadth, phenotype, function, and specificity of Gag-specific T cells induced by a DNA-prime modified vaccinia virus Ankara (MVA)-boost vaccination strategy, which uses mismatched Gag immunogens in the TamoVac 01 phase IIa trial. Healthy Tanzanian volunteers received three injections of the DNA-SMI vaccine encoding a subtype B and AB-recombinant Gag

Indexed as

AIDS VaccinesDrug Carriersgag Gene Products, Human Immunodeficiency VirusHealthy VolunteersHIV-1HumansInterferon-gammaInterleukin-2TanzaniaT-LymphocytesT-Lymphocyte SubsetsTumor Necrosis Factor-alphaVaccinationVaccines, DNAVaccines, SubunitVaccines, SyntheticAIDS VaccinesDrug Carriersgag Gene Products, Human Immunodeficiency VirusIL2 protein, humanInterferon-gammaInterleukin-2Tumor Necrosis Factor-alphaVaccines, DNAVaccines, SubunitVaccines, SyntheticGaghuman immunodeficiency virusT cellsvaccines

Identifiers

PMID28701395
PMCPMC5571275
OpenAlexW2735115013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.