Evidence map›Paper›PMID 28701345›Full record

ArticleMolecular biology of the cell2017

TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.

Melissa Plooster, Shalini Menon, Cortney C Winkle, Fabio L Urbina, Caroline Monkiewicz, Kristen D Phend, Richard J Weinberg, Stephanie L Gupton

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Article
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  5. Article
  6. Emerging roles for E3 ubiquitin ligases in neural development and disease.Frontiers in cell and developmental biology · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Automated Detection and Analysis of Exocytosis.Journal of visualized experiments : JoVE · 2021
    Article
  19. Article
  20. The ubiquitylome of developing cortical neurons.microPublication biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Melissa PloosterCell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Shalini MenonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Cortney C WinkleNeurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Fabio L UrbinaCell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Caroline MonkiewiczDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Kristen D PhendDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Richard J WeinbergDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Stephanie L GuptonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 sgupton@email.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

TRIM9 coordinates membrane trafficking and cytoskeletal dynamicsR01GM108970 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GUPTON, STEPHANIE · 2014 to 2018
$1.6M
Training in Mechanistic, Interdisciplinary Studies of Biological SystemsT32GM119999 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2017 to 2021
$1.2M
Identification of ubiquitnated substrates of TRIM9 and TRIM67R21MH109653 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GUPTON, STEPHANIE · 2016 to 2017
$417k
TRIM9 controls signaling downstream of Netrin in axon branching and guidanceF31NS087837 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WINKLE, CORTNEY · 2014 to 2015
$61k
NIGMS NIH HHS R01 GM108970NIGMS NIH HHS T32 GM119999NIMH NIH HHS R21 MH109653NINDS NIH HHS F31 NS087837
6 · The paper itself

Abstract

Extracellular netrin-1 and its receptor deleted in colorectal cancer (DCC) promote axon branching in developing cortical neurons. Netrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, yet how these occurrences are linked is unknown. Here we demonstrate that

Indexed as

AnimalsAxonsCarrier ProteinsCell MembraneDCC ReceptorExocytosisFemaleFocal Adhesion Kinase 1HEK293 CellsHumansMaleMembrane FusionMiceNerve Tissue ProteinsNetrin-1NeurogenesisCarrier ProteinsDCC protein, humanDcc protein, mouseDCC ReceptorFocal Adhesion Kinase 1Nerve Tissue ProteinsNetrin-1Ntn1 protein, mousePtk2 protein, mousesrc-Family KinasesTRIM9 protein, humanTrim9 protein, mouseTripartite Motif ProteinsUbiquitin-Protein Ligases

Identifiers

PMID28701345
PMCPMC5576901
OpenAlexW2674633682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.