Evidence map›Paper›PMID 28701344›Full record

ArticleMolecular biology of the cell2017

Syp1 regulates the clathrin-mediated and clathrin-independent endocytosis of multiple cargo proteins through a novel sorting motif.

Amanda Reider Apel, Kyle Hoban, Silvia Chuartzman, Raffi Tonikian, Sachdev Sidhu, Maya Schuldiner, Beverly Wendland, Derek Prosser

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Endocytosis and trans-Golgi Network in Yeast.Sub-cellular biochemistry · 2026
    Review
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. A CIE change in our understanding of endocytic mechanisms.Frontiers in cell and developmental biology · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Amanda Reider ApelDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.
Kyle HobanDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.
Silvia ChuartzmanDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Raffi TonikianDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Sachdev SidhuDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Maya SchuldinerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Beverly WendlandDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.
Derek ProsserDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218 dprosser@vcu.edu.
Johns Hopkins University · USUniversity of Toronto · CAWeizmann Institute of Science · IL

Funding

MOLECULAR ANALYSIS OF ENDOCYTOSIS PROTEINS IN YEASTR01GM060979 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WENDLAND, BEVERLY R · 2000 to 2013
$4.3M
NIGMS NIH HHS R01 GM060979
6 · The paper itself

Abstract

Internalization of proteins from the plasma membrane (PM) allows for cell-surface composition regulation, signaling of network modulation, and nutrient uptake. Clathrin-mediated endocytosis (CME) is a major internalization route for PM proteins. During CME, endocytic adaptor proteins bind cargoes at the cell surface and link them to the PM and clathrin coat. Muniscins are a conserved family of endocytic adaptors, including Syp1 in budding yeast and its mammalian orthologue, FCHo1. These adaptors bind cargo via a C-terminal

Indexed as

Adaptor Proteins, Vesicular TransportBiological TransportCarrier ProteinsCell MembraneClathrinEndocytosisMembrane Transport ProteinsPlasmidsProtein TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSNARE ProteinsAdaptor Proteins, Vesicular TransportCarrier ProteinsClathrinMembrane Transport ProteinsSaccharomyces cerevisiae ProteinsSNARE ProteinsSyp1 protein, S cerevisiae

Identifiers

PMID28701344
PMCPMC5576906
OpenAlexW2734772393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.