Evidence map›Paper›PMID 28701304›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.

Kemly Philip, Tingting Weng Mills, Jonathan Davies, Ning-Yuan Chen, Harry Karmouty-Quintana, Fayong Luo, Jose G Molina, Javier Amione-Guerra, Neeraj Sinha, Ashrith Guha and 2 more

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 77 citations in OpenAlex.

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  14. Ivy Leaf Dry Extract EA 575International journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Kemly PhilipDepartment of Biochemistry and Molecular Biology McGovern Medical School at UTHealth, Houston, Texas, USA.
Tingting Weng MillsDepartment of Biochemistry and Molecular Biology McGovern Medical School at UTHealth, Houston, Texas, USA.
Jonathan DaviesDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA; and.
Ning-Yuan ChenDepartment of Biochemistry and Molecular Biology McGovern Medical School at UTHealth, Houston, Texas, USA.
Harry Karmouty-QuintanaDepartment of Biochemistry and Molecular Biology McGovern Medical School at UTHealth, Houston, Texas, USA.
Fayong LuoDepartment of Biochemistry and Molecular Biology McGovern Medical School at UTHealth, Houston, Texas, USA.
Jose G MolinaDepartment of Biochemistry and Molecular Biology McGovern Medical School at UTHealth, Houston, Texas, USA.
Javier Amione-GuerraJ. C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, Texas, USA.
Neeraj SinhaJ. C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, Texas, USA.
Ashrith GuhaJ. C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, Texas, USA.
Holger K EltzschigDepartment of Anesthesiology, McGovern Medical School at UTHealth, Houston, Texas, USA.
Michael R BlackburnDepartment of Biochemistry and Molecular Biology McGovern Medical School at UTHealth, Houston, Texas, USA; Michael.R.Blackburn@uth.tmc.edu.
The University of Texas Health Science Center · USMethodist Hospital · USBaylor College of Medicine · USThe University of Texas Health Science Center at Houston · US

Funding

Trangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLACKBURN, MICHAEL R · 2013 to 2017
$10.0M
Proton Pump Inhibitors for Perioperative Acute Kidney InjuryR01DK097075 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2013 to 2017
$1.7M
Amphiregulin Signaling in Perioperative Cardio-ProtectionR01HL119837 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2014 to 2017
$1.5M
NHLBI NIH HHS P01 HL114457NHLBI NIH HHS R01 HL119837NIDDK NIH HHS R01 DK097075
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a deadly chronic lung disease. Extracellular accumulation of adenosine and subsequent activation of the ADORA2B receptor play important roles in regulating inflammation and fibrosis in IPF. Additionally, alternatively activated macrophages (AAMs) expressing ADORA2B have been implicated in mediating adenosine's effects in IPF. Although hypoxic conditions are present in IPF, hypoxia's role as a direct modulator of macrophage phenotype and identification of factors that regulate ADORA2B expression on AAMs in IPF is not well understood. In this study, an experimental mouse model of pulmonary fibrosis and lung samples from patients with IPF were used to examine the effects and interactions of macrophage differentiation and hypoxia on fibrosis. We demonstrate that hypoxia-inducible factor 1-α (HIF1A) inhibition in late stages of bleomycin-induced injury attenuates pulmonary fibrosis in association, with reductions in ADORA2B expression in AAMs. Additionally, ADORA2B deletion or pharmacological antagonism along with HIF1A inhibition disrupts AAM differentiation and subsequent IL-6 production in cultured macrophages. These findings suggest that hypoxia, through HIF1A, contributes to the development and progression of pulmonary fibrosis through its regulation of ADORA2B expression on AAMs, cell differentiation, and production of profibrotic mediators. These studies support a potential role for HIF1A or ADORA2B antagonists in the treatment of IPF.-Philip, K., Mills, T. W., Davies, J., Chen, N.-Y., Karmouty-Quintana, H., Luo, F., Molina, J. G., Amione-Guerra, J., Sinha, N., Guha, A., Eltzschig, H. K., Blackburn, M. R. HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.

Indexed as

Macrophages, AlveolarUp-RegulationAdultAgedAnimalsBleomycinCell HypoxiaCells, CulturedFemaleHumansHypoxia-Inducible Factor 1, alpha SubunitInterleukin-6MacrophagesMaleMiceMice, TransgenicBleomycinHIF1A protein, humanHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitIL6 protein, humanInterleukin-6Receptor, Adenosine A2Badenosine receptorshypoxiaidiopathic pulmonary fibrosis

Identifiers

PMID28701304
PMCPMC5636704
OpenAlexW2734568032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.