ReviewJournal of ovarian research2017
Follicular Fluid redox involvement for ovarian follicle growth.
Review in Journal of ovarian research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Follicular fluid composition and reproductive outcomes of women with polycystic ovary syndrome undergoing in vitro fertilization: A systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Review
- Identification of the optimal manipulation medium temperature for in vitro handling of oocytes and embryos during in vitro maturation, parthenogenesis, and in vitro culture in pigs.The Journal of reproduction and development · 2026Article
- Molecular characteristics of follicular fluid in advanced maternal age women with different ovarian reserves: a multi-omics study.BMC women's health · 2026Article
- FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination.Journal of nanobiotechnology · 2026Article
- Oxidative-antioxidant status of follicular fluid in IVF patients: Influence of ovarian response and oocyte-cumulus complex morphology.JBRA assisted reproduction · 2026Article
- Gestational exposure to the artificial sweetener erythritol reprograms ovarian function through AMH suppression and oxidative stress-mediated disruption of autophagy and PI3K signaling.Frontiers in endocrinology · 2026Article
- Mapping the Nitric Oxide Axis in IVF: Genotype Associations in Antagonist Cycles.International journal of molecular sciences · 2025Article
- Correlation between AMH levels and embryonic aneuploidy rate in PGT-A patients: a retrospective study.Journal of assisted reproduction and genetics · 2025Article
- Identification of Proteins and MicroRNAs with Prognostic Value for Assisted Reproduction Technology Outcomes in Follicular Fluid of Women with Endometriosis: A Pilot Study.International journal of molecular sciences · 2025Article
- First follicular fluid cf-mtDNA sequencing unveils ovarian stimulation-induced mutations impacting oocyte quality and IVF success.Journal of assisted reproduction and genetics · 2025Article
- Does diminished ovarian reserve impact oxidation-reduction potential in follicular fluid?The Journal of international medical research · 2025Article
- PTX3/NF-κB/TLR4 Pathway Evaluation in the Follicular Fluid to Successfully Predict Blastocyst Implantation: A Pilot Study.Biomedicines · 2025Article
- Incubation of semen with human follicular fluid improves the antioxidant status and quality of spermatozoa after freezing-thawing.Reproduction & fertility · 2025Article
- Redox profiling of preovulatory follicular fluid in the donkey is species-specific, and contributes to modulate sperm function.Scientific reports · 2025Article
- Short Supply of High Levels of Guanidine Acetic Acid, Alters Ovarian Artery Flow and Improves Intraovarian Blood Perfusion Area Associated with Follicular Growth in Sheep.Animals : an open access journal from MDPI · 2025Article
- Oxidative Homeostasis in Follicular Fluid and Embryo Quality-A Pilot Study.International journal of molecular sciences · 2025Article
- Unraveling the complexity of follicular fluid: insights into its composition, function, and clinical implications.Journal of ovarian research · 2024Review
- Identification of metabolomic changes and potential therapeutic targets during ovarian aging.Aging · 2024Article
- Changes in Rehmanniae Radix processing and their impact on ovarian hypofunction: potential mechanisms of action.Frontiers in pharmacology · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a reservoir rich in biomolecules. In some aspects, it is similar to the plasma, but it also exhibits differences that likely relate to its specific localization around the oocyte. The chemical composition indicates that the follicular fluid is able to detect and buffer excessive amounts of reactive oxygen species, employing a variety of antioxidants, some of them components of the intracellular milieu.An important part is played by albumin through specific cysteine residues. But the fluid contains other molecules whose cysteine residues may be involved in sensing and buffering the local oxidative conditions. How these molecules are recruited and regulated to intervene such process is unknown but it is a critical issue in reproduction.In fact, important proteins in the FF, that regulate follicle growth and oocyte quality, exhibit cysteine residues at specific points, whose untoward oxidation would result in functional loss. Therefore, preservation of controlled oxidative conditions in the FF is a requirement for the fine-tuned oocyte maturation process. In contrast, its disturbance enhances the susceptibility to the establishment of reproductive disorders that would require the intervention of reproductive medicine technology.
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