ArticleEuropean journal of medical research2017
A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α.
Article in European journal of medical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 5 of them syntheses that pooled it.
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Who cites it
182 citing papers in PubMed, 5 syntheses or guidelines pooled it, 280 citations in OpenAlex.
- Effects of exercise interventions on inflammatory biomarker levels in older adults with frailty and/or sarcopenia: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Sex-stratified handgrip strength and adipose-derived inflammatory biomarkers in sarcopenia - a systematic review and meta-analysis.BMC geriatrics · 2025Pooled it
- Association of interleukin-6 with sarcopenia and its components in older adults: a systematic review and meta-analysis of cross-sectional studies.Annals of medicine · 2024Pooled it
- Pooled it
- Sarcopenia as a predictor of mortality in women with breast cancer: a meta-analysis and systematic review.BMC cancer · 2020Pooled it
- Trial
- Fish Oil Supplementation with Resistance Exercise Training Enhances Physical Function and Cardiometabolic Health in Postmenopausal Women.Nutrients · 2023Trial
- Fish oil administration combined with resistance exercise training improves strength, resting metabolic rate, and inflammation in older adults.Aging clinical and experimental research · 2022Trial
- Trial
- Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial.Nutrients · 2020Trial
- Combined Impact of Sarcopenia and Low Visceral Adiposity on Postoperative Outcomes and Survival After Esophagectomy for Esophageal Cancer.Annals of surgical oncology · 2026Article
- Integrative Analysis Uncover the Effects and Multi-Omics Features of Thigh Muscle Fat Infiltration.Aging cell · 2026Article
- Biomarkers and Early Mechanisms of Sarcopenia: Central Roles of Mitochondrial Dysfunction, Inflammaging, Cellular Senescence, and Neuromuscular Degeneration.International journal of molecular sciences · 2026Review
- Association between atrial fibrillation and systemic inflammation with muscle mass and strength trajectories in old age.GeroScience · 2026Article
- Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion.The Journal of infectious diseases · 2026Article
- Article
- The systemic inflammation response index is independently associated with incident fracture risk in older women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Association of dynapenic abdominal obesity with prevalence and incidence of symptomatic knee osteoarthritis among the middle-aged and older Chinese.Aging clinical and experimental research · 2026Article
- Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway.NAR molecular medicine · 2026Article
- An integrated drug repositioning analysis identifies rosiglitazone as a treatment for sarcopenia.Communications biology · 2026Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-α.
methodsA total of 441 elders who undertook physical examinations were included into this study. The age of these subjects were >60, in which 235 subjects were male and 206 subjects were female. According to the diagnostic standards of sarcopenia set by EWGSOP and AWGS, these subjects were divided into two groups: sarcopenia, and non-sarcopenia groups. The living habits, disease status, biochemical indexes, and levels of IL-6 and TNF-α of these subjects were investigated.
resultsThe morbidity rate of sarcopenia was 17.02% in male subjects and 18.9% in female subjects. In elderly subjects >80 years old, morbidity rate was 25.3% in male subjects and 35.1% in female subjects. The history of smoking in patients with sarcopenia was long, and their regular exercise history was short (P < 0.01). Furthermore, differences in handgrip strength (HG), fat-free mass (FFM), bone mineral content (BMC), plasma albumin (ALB) and serum creatinine (Cr), and body fat content (FAT) in patients between the sarcopenia and non-sarcopenia groups were statistically significant (P < 0.05). Moreover, differences in IL-6 and TNF-α levels between these two groups were statistically significant (P < 0.05). In addition, BMI was positively correlated to TNF-α levels, and ALB was negatively correlated to IL-6; while BMI and VFA were positively correlated to TNF-α levels, and SMM, HDL-C, Hb, HG were negatively correlated to IL-6 level (P < 0.05). Multiple linear regression analysis suggested plasma ALB and BMI were the independent risk factors of TNF-α, while VFA was the independent risk factor of IL-6.
conclusionsThe onset of sarcopenia was associated with poor exercise habits, disease history, and nutritional status. The emergence of sarcopenia was accompanied by increased levels of inflammation factors TNF-α and IL-6. Plasma albumin, BMI, and VFA were inflammatory factor predictors of TNF and IL-6.
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