ArticleBMC infectious diseases2017
Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Pertussis-SARS-CoV-2 Co-infection in Infants at Mohammed VI University Hospital, Marrakech, Morocco.Cureus · 2026Article
- Risk factors for pneumonia in children withOpen medicine (Warsaw, Poland) · 2026Article
- Bordetella Pertussis in Children: A Retrospective Analysis of the Clinical Impact and the Role of Vaccination.Life (Basel, Switzerland) · 2025Article
- Beyond Passive Immunity: Three Neonatal Influenza Cases Highlighting Impact of Missed Maternal Vaccination.Clinics and practice · 2025Article
- Co-infection in unvaccinated infants with acute pertussis in Western China (2018-2019): pathogen distribution and impact on disease severity.Italian journal of pediatrics · 2025Article
- A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease.Italian journal of pediatrics · 2025Article
- Co-infection in pediatric pertussis during 2023 and 2024 in southern China: pathogen distribution characteristic and influence on manifestation of pertussis.Frontiers in microbiology · 2025Article
- Association between real-time polymerase chain reaction cycle threshold value and clinical presentation in children with Bordetella pertussis.Italian journal of pediatrics · 2024Article
- Trend of pathogens and respiratory co-infections in the province of Messina: from pediatric age to senescence.Journal of preventive medicine and hygiene · 2024Article
- Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Article
- Evaluation of BioFire Respiratory Panel 2Microbiology spectrum · 2023Article
- The burden of viral lower respiratory tract infections during the neonatal period: six-year experience at a tertiary referral hospital.Croatian medical journal · 2022Article
- Impact of the COVID-19 pandemic on Bordetella pertussis infections in England.BMC public health · 2022Article
- Automatic Identification of MALDI-TOF MS Database Using ClassicalComputational and mathematical methods in medicine · 2022Article
- Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection.Scientific reports · 2021Article
- Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection.Scientific reports · 2021Article
- Pertussis in Italy: how to protect the "unprotectable"?Human vaccines & immunotherapeutics · 2021Observational
- Pertussis in early life: underdiagnosed, severe, and risky disease. A seven-year experience in a pediatric tertiary-care hospital.Human vaccines & immunotherapeutics · 2021Article
- Virus Coinfection is a Predictor of Radiologically Confirmed Pneumonia in Children with Bordetella pertussis Infection.Infectious diseases and therapy · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also analyzed how respiratory infections were distributed during the 2 years study.
methodsWe enrolled 53 infants with pertussis younger than 180 days (median age 58 days, range 17–109 days, 64. 1% boys), hospitalized in the Pediatric Departments at “Sapienza” University Rome and Bambino Gesù Children’s Hospital from August 2012 to November 2014. We tested in naso-pharyngeal washings B. pertussis and 14 respiratory viruses with real-time reverse-transcriptase-polymerase chain reaction. Clinical data were obtained from hospital records and demographic characteristics collected using a structured questionnaire.
results28/53 infants had B. pertussis alone and 25 viral coinfection: 10 human rhinovirus (9 alone and 1 in coinfection with parainfluenza virus), 3 human coronavirus, 2 respiratory syncytial virus. No differences were observed in clinical disease severity between infants with B. pertussis infection alone and those with coinfections. Infants with B. pertussis alone were younger than infants with coinfections, and less often breastfeed at admission.
conclusionsIn this descriptive study, no associations between clinical severity and pertussis with or without co-infections were found.
trial registrationPoliclinico Umberto I: protocol 213/14, 3085/13.02.2014, retrospectively registered. Bambino Gesù Children’s Hospital: protocol n. RF-2010-2317709.
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