ArticleBiophysical journal2017
Dynamic Model Exposes the Energetics and Dynamics of the Injection Machinery for Bacteriophage T4.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Review
- Structural dynamics of contractile injection systems.Biophysical journal · 2025Article
- Quantitative description of a contractile macromolecular machine.Science advances · 2021Article
- Linearized Bayesian inference for Young's modulus parameter field in an elastic model of slender structures.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- How the phage T4 injection machinery works including energetics, forces, and dynamic pathway.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- How Viruses Enter Cells: A Story behind Bacteriophage T4.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophage T4 infects the bacterial host (Escherichia coli) using an efficient genomic delivery machine that is driven by elastic energy stored in a contractile tail sheath. Although the atomic structure of T4 is largely known, the dynamics of its fascinating injection machinery is not understood. This article contributes, to our knowledge, the first predictions of the energetics and dynamics of the T4 injection machinery using a novel dynamic model. The model employs an atomistic (molecular dynamics) representation of a fraction of the sheath structure to generate a continuum model of the entire sheath that also couples to a model of the viral capsid and tail tube. The resulting model of the entire injection machine reveals estimates for the energetics, timescale, and pathway of the T4 injection process as well as the force available for cell rupture. It also reveals the large and highly nonlinear conformational changes of the sheath whose elastic energy drives the injection process.
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