Evidence map›Paper›PMID 28700915›Full record

ArticleBiophysical journal2017

A Model for Adult Organ Resizing Demonstrates Stem Cell Scaling through a Tunable Commitment Rate.

XinXin Du, Lucy Erin O'Brien, Ingmar Hans Riedel-Kruse

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

XinXin DuDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, California; Department of Bioengineering, Stanford University, Stanford, California.
Lucy Erin O'BrienDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, California. Electronic address: lucye@stanford.edu.
Ingmar Hans Riedel-KruseDepartment of Bioengineering, Stanford University, Stanford, California. Electronic address: ingmar@stanford.edu.
Stanford University · US

Funding

Dynamic Mechanisms of Fate Control during Epithelial Organ RenewalR01GM116000 · NIGMS · STANFORD UNIVERSITY · PI O'BRIEN, LUCY ERIN · 2016 to 2020
$1.6M
FRET-based tension-sensors for studying zebrafish developmentR21HD080553 · NICHD · STANFORD UNIVERSITY · PI DUNN, ALEXANDER R, RIEDEL-KRUSE, HANS INGMAR · 2014 to 2015
$307k
Mechanical force and response during stem cell divisions in a self-renewing epithelial organF32GM115065 · NIGMS · STANFORD UNIVERSITY · PI DU, XINXIN · 2015 to 2016
$112k
NICHD NIH HHS R21 HD080553NIGMS NIH HHS F32 GM115065NIGMS NIH HHS R01 GM116000
6 · The paper itself

Abstract

Many adult organs grow or shrink to accommodate different physiological demands. Often, as total cell number changes, stem cell number changes proportionally in a phenomenon called "stem cell scaling". The cellular behaviors that give rise to scaling are unknown. Here we study two complementary theoretical models of the adult Drosophila midgut, a stem cell-based organ with known resizing dynamics. First, we derive a differential equations model of midgut resizing and show that the in vivo kinetics of growth can be recapitulated if the rate of fate commitment depends on the tissue's stem cell proportion. Second, we develop a 2D simulation of the midgut and find that proportion-dependent commitment rate and stem cell scaling can arise phenomenologically from the stem cells' exploration of physical tissue space during its lifetime. Together, these models provide a biophysical understanding of how stem cell scaling is maintained during organ growth and shrinkage.

Indexed as

Models, BiologicalOrgan SizeAnimalsComputer SimulationDrosophilaDrosophila ProteinsGastrointestinal TractIntracellular Signaling Peptides and ProteinsKineticsMembrane ProteinsReceptors, NotchSignal TransductionStem Cellsdelta proteinDrosophila ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsN protein, DrosophilaReceptors, Notch

Identifiers

PMID28700915
PMCPMC5510814
OpenAlexW2952434513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.